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Tchem
BCL2L10
Bcl-2-like protein 10

Protein Summary
Description
Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260442
  • ENSP00000260442
  • ENSG00000137875

Symbol
  • BCLB
  • Boo
  • Diva
  • BCL-B
  • bcl2-L-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.69
cellular component
0.65
tissue sample
0.59
protein domain
0.58
cell type or tissue
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.8   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.8   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (72)
BAX
Tchem
Novelty:  0.00150653
p_int:  0.997268349
p_ni:  0.002731651
Score:  0.473
Data Source:  BioPlex,STRINGDB
EID2
Tbio
Novelty:  0.02022264
p_int:  0.992325771
p_ni:  3.01e-7
p_wrong:  0.007673929
Data Source:  BioPlex
BCL2L11
Tchem
Novelty:  0.00055914
p_int:  0.959083099
p_ni:  0.015326069
p_wrong:  0.025590831
Score:  0.959
Data Source:  BioPlex,STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.818
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.733
Data Source:  STRINGDB
BCL2L2
Tchem
Novelty:  0.00430896
Score:  0.702
Data Source:  STRINGDB
BIK
Tbio
Novelty:  0.0046334
Score:  0.687
Data Source:  STRINGDB
HHAT
Tchem
Family:  Enzyme
Novelty:  0.003077
Score:  0.67
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.651
Data Source:  STRINGDB
BCL2A1
Tchem
Novelty:  0.00088899
Score:  0.648
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
46.1
heel bone mineral density
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
46.1
heel bone mineral density
1
8.1
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 10
VGNC:6459
467685
Macaque
BCL2 like 10
695562
Mouse
MGI:1330841
12049
Rat
RGD:621015
114552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 10
Macaque
BCL2 like 10
Mouse
Rat
Publication Statistics
PubMed Score 80.80
PubMed score by year
PubTator Score 56.79
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title