Tbio LYRM4 LYR motif-containing protein 4

Protein Summary

Description

Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9HD34
• A8K543
• Q5XKP1

Gene Name

• LYRM4

Ensembl ID

• ENST00000330636
• ENSP00000418787
• ENSG00000214113

Symbol

• C6orf149
• ISD11
• ISD11
• CGI-203
• COXPD19
• C6orf149

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
trait	0.86
transcription factor binding site profile	0.7
cell type or tissue	0.62
microRNA	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.48   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.48   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0