Tchem GOPC Golgi-associated PDZ and coiled-coil motif-containing protein

Protein Summary

Description

Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9HD26
• A6NM30
• Q59FS4
• Q969U8

Gene Name

• GOPC

Ensembl ID

• ENST00000052569
• ENSP00000052569
• ENSG00000047932
• ENST00000368498
• ENSP00000357484

Symbol

• CAL
• FIG
• CAL
• FIG
• PIST
• GOPC1
• dJ94G16.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
interacting protein	0.88
histone modification site profile	0.74
transcription factor perturbation	0.74
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.65   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 442   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.65   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0