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Tbio
GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

Protein Summary
Description
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000052569
  • ENSP00000052569
  • ENSG00000047932
  • ENST00000368498
  • ENSP00000357484

Symbol
  • CAL
  • FIG
  • CAL
  • FIG
  • PIST
  • GOPC1
  • dJ94G16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
interacting protein
0.88
histone modification site profile
0.74
transcription factor perturbation
0.74
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.9   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 442   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.9   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
ZBTB5
Tbio
Novelty:  0.50774653
p_int:  0.999999927
p_ni:  7e-8
p_wrong:  3e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
FAM9A
Tdark
Novelty:  0.72563725
p_int:  0.999999254
p_ni:  7.46e-7
Data Source:  BioPlex
RTL6
Tbio
Novelty:  0.12824182
p_int:  0.999998426
p_ni:  7.88e-7
p_wrong:  7.86e-7
Score:  0.359
Data Source:  BioPlex,STRINGDB
FCHSD2
Tbio
Novelty:  0.01879431
p_int:  0.999997467
p_ni:  0.000002495
p_wrong:  3.8e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
ATG4D
Tbio
Family:  Enzyme
Novelty:  0.07285957
p_int:  0.999995729
p_ni:  7.49e-7
p_wrong:  0.000003522
Score:  0.196
Data Source:  BioPlex,STRINGDB
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.999995523
p_ni:  0.000004458
p_wrong:  1.8e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.99999548
p_ni:  0.00000452
Score:  0.152
Data Source:  BioPlex,STRINGDB
CNTLN
Tbio
Novelty:  0.0044959
p_int:  0.999995434
p_ni:  5.6e-8
p_wrong:  0.00000451
Score:  0.189
Data Source:  BioPlex,STRINGDB
MIS18BP1
Tbio
Novelty:  0.05688807
p_int:  0.999993598
p_ni:  0.000006402
Data Source:  BioPlex
PML
Tbio
Novelty:  0.00285474
p_int:  0.999988706
p_ni:  0.000011294
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases regulate CFTR trafficking
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases regulate CFTR trafficking
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
3
1.1
83.6
1
1
0
1.2
39.6
1
1
0
1.1
30.2
insomnia measurement
1
1
0
1
24.5
anthropometric measurement
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
83.6
0
1.2
39.6
0
1.1
30.2
insomnia measurement
0
1
24.5
anthropometric measurement
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi associated PDZ and coiled-coil motif containing
VGNC:11085
462964
Mouse
MGI:2149946
94221
Rat
RGD:1309512
309774
Dog
golgi associated PDZ and coiled-coil motif containing
VGNC:49713
484100
Cow
golgi associated PDZ and coiled-coil motif containing
VGNC:53793
541186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi associated PDZ and coiled-coil motif containing
Mouse
Rat
Dog
golgi associated PDZ and coiled-coil motif containing
Cow
golgi associated PDZ and coiled-coil motif containing
Publication Statistics
PubMed Score 89.90
PubMed score by year
PubTator Score 52.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title