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Tbio
GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

Protein Summary
Description
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000052569
  • ENSP00000052569
  • ENSG00000047932
  • ENST00000368498
  • ENSP00000357484

Symbol
  • CAL
  • FIG
  • CAL
  • FIG
  • PIST
  • GOPC1
  • dJ94G16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
interacting protein
0.88
histone modification site profile
0.74
transcription factor perturbation
0.74
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.38   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 442   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.38   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi associated PDZ and coiled-coil motif containing
VGNC:11085
462964
Mouse
MGI:2149946
94221
Rat
RGD:1309512
309774
Dog
golgi associated PDZ and coiled-coil motif containing
VGNC:49713
484100
Cow
golgi associated PDZ and coiled-coil motif containing
VGNC:53793
541186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi associated PDZ and coiled-coil motif containing
Mouse
Rat
Dog
golgi associated PDZ and coiled-coil motif containing
Cow
golgi associated PDZ and coiled-coil motif containing
Protein Structure (28 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HD26-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases regulate CFTR trafficking
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases regulate CFTR trafficking
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (22)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (128)
1 – 10 of 128
ZBTB5
Tbio
Novelty: 0.50774653
p_int: 0.999999927
p_ni: 7e-8
p_wrong: 3e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
FAM9A
Tdark
Novelty: 0.72563725
p_int: 0.999999254
p_ni: 7.46e-7
Data Source: BioPlex
RTL6
Tbio
Novelty: 0.12824182
p_int: 0.999998426
p_ni: 7.88e-7
p_wrong: 7.86e-7
Score: 0.359
Data Source: BioPlex,STRINGDB
FCHSD2
Tbio
Novelty: 0.01879431
p_int: 0.999997467
p_ni: 0.000002495
p_wrong: 3.8e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
ATG4D
Tbio
Family: Enzyme
Novelty: 0.07285957
p_int: 0.999995729
p_ni: 7.49e-7
p_wrong: 0.000003522
Score: 0.196
Data Source: BioPlex,STRINGDB
BAP1
Tbio
Family: Enzyme
Novelty: 0.00501435
p_int: 0.999995523
p_ni: 0.000004458
p_wrong: 1.8e-8
Score: 0.181
Data Source: BioPlex,STRINGDB
C5orf24
Tdark
Novelty: 3.95177775
p_int: 0.99999548
p_ni: 0.00000452
Score: 0.152
Data Source: BioPlex,STRINGDB
CNTLN
Tbio
Novelty: 0.0044959
p_int: 0.999995434
p_ni: 5.6e-8
p_wrong: 0.00000451
Score: 0.189
Data Source: BioPlex,STRINGDB
MIS18BP1
Tbio
Novelty: 0.05688807
p_int: 0.999993598
p_ni: 0.000006402
Data Source: BioPlex
PML
Tbio
Novelty: 0.00285474
p_int: 0.999988706
p_ni: 0.000011294
Data Source: BioPlex
Publication Statistics
PubMed Score  85.38

PubMed score by year
PubTator Score  52.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer