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Tbio
MRS2
Magnesium transporter MRS2 homolog, mitochondrial

Protein Summary
Description
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378353
  • ENSP00000367604
  • ENSG00000124532
  • ENST00000378386
  • ENSP00000367637
  • ENST00000443868
  • ENSP00000399585

Symbol
  • HPT
  • MRS2L
  • HPT
  • MRS2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
kinase perturbation
0.76
histone modification site profile
0.73
microRNA
0.73
cellular component
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
ZNF133
Tbio
Family:  TF
Novelty:  0.20117958
p_int:  0.999954079
p_ni:  0.000045921
Data Source:  BioPlex
SYP
Tbio
Novelty:  0.00021543
p_int:  0.997940383
p_ni:  0.002059617
Data Source:  BioPlex
NOL9
Tdark
Family:  Enzyme
Novelty:  0.05830272
p_int:  0.997923845
p_ni:  0.002076155
Score:  0.157
Data Source:  BioPlex,STRINGDB
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
p_int:  0.997443771
p_ni:  0.002556229
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.997019253
p_ni:  0.002980747
Data Source:  BioPlex
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.992321946
p_ni:  0.007678054
Data Source:  BioPlex
TBC1D15
Tbio
Novelty:  0.11296513
p_int:  0.991373464
p_ni:  0.008626536
Data Source:  BioPlex
MRPL35
Tdark
Novelty:  0.30867276
p_int:  0.990742502
p_ni:  0.009257498
Score:  0.157
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.989495947
p_ni:  0.010504053
Data Source:  BioPlex
ZNF747
Tdark
Novelty:  9
p_int:  0.988470807
p_ni:  0.011529193
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
5
8
6
18.4
99.6
liver enzyme measurement
1
1
1
50.6
serum gamma-glutamyl transferase measurement
1
1
1
49.5
protein measurement
1
1
1
49.5
serum albumin measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
18.4
99.6
liver enzyme measurement
1
50.6
serum gamma-glutamyl transferase measurement
1
49.5
protein measurement
1
49.5
serum albumin measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MRS2, magnesium transporter
VGNC:3493
462472
Macaque
MRS2, magnesium transporter
707676
Mouse
MGI:2685748
380836
Rat
RGD:708529
79032
Dog
MRS2, magnesium transporter
VGNC:43429
488245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MRS2, magnesium transporter
Macaque
MRS2, magnesium transporter
Mouse
Rat
Dog
MRS2, magnesium transporter
Publication Statistics
PubMed Score 396.89
PubMed score by year
PubTator Score 34.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title