Tbio MRS2 Magnesium transporter MRS2 homolog, mitochondrial

Protein Summary

Description

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Uniprot Accession IDs

• Q9HD23
• A8K4U3
• B3KNN2
• B4DQL2
• Q5T3Y1
• Q6NTG4
• Q96KF8
• Q9BVP1

Gene Name

• MRS2

Ensembl ID

• ENST00000378353
• ENSP00000367604
• ENSG00000124532
• ENST00000378386
• ENSP00000367637
• ENST00000443868
• ENSP00000399585

Symbol

• HPT
• MRS2L
• HPT
• MRS2L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
kinase perturbation	0.76
histone modification site profile	0.73
microRNA	0.73
cellular component	0.7

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Magnesium Transporter Mrs2 Homolog, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 707.67   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 707.67   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0