MRS2
Magnesium transporter MRS2 homolog, mitochondrial
Protein Summary
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).
- ENST00000378353
- ENSP00000367604
- ENSG00000124532
- ENST00000378386
- ENSP00000367637
- ENST00000443868
- ENSP00000399585
- HPT
- MRS2L
- HPT
- MRS2L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.8 | ||
kinase perturbation | 0.76 | ||
histone modification site profile | 0.73 | ||
microRNA | 0.73 | ||
cellular component | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 396.89 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 53 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 396.89 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 53 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (75)
NOL9
Family: Enzyme
Novelty: 0.05830272
p_int: 0.997923845
p_ni: 0.002076155
Score: 0.157
Data Source: BioPlex,STRINGDB
CHST8
Family: Enzyme
Novelty: 0.03489772
p_int: 0.997443771
p_ni: 0.002556229
Data Source: BioPlex
LPAR1
Family: GPCR
Novelty: 0.00318056
p_int: 0.997019253
p_ni: 0.002980747
Data Source: BioPlex
MRPL35
Novelty: 0.30867276
p_int: 0.990742502
p_ni: 0.009257498
Score: 0.157
Data Source: BioPlex,STRINGDB
SAP18
Family: Enzyme
Novelty: 0.03918373
p_int: 0.989495947
p_ni: 0.010504053
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Miscellaneous transport and binding events | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Miscellaneous transport and binding events | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 5 | 8 | 6 | 18.4 | 99.6 | ||||
liver enzyme measurement | 1 | 1 | 1 | 50.6 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 49.5 | |||||
protein measurement | 1 | 1 | 1 | 49.5 | |||||
serum albumin measurement | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 6 | 18.4 | 99.6 | ||||
liver enzyme measurement | 1 | 50.6 | |||||
serum gamma-glutamyl transferase measurement | 1 | 49.5 | |||||
protein measurement | 1 | 49.5 | |||||
serum albumin measurement | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MRS2, magnesium transporter | VGNC:3493 | 462472 | |||||
Macaque | MRS2, magnesium transporter | 707676 | ||||||
Mouse | MGI:2685748 | 380836 | ||||||
Rat | RGD:708529 | 79032 | ||||||
Dog | MRS2, magnesium transporter | VGNC:43429 | 488245 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MRS2, magnesium transporter | |||||
Macaque | MRS2, magnesium transporter | |||||
Mouse | ||||||
Rat | ||||||
Dog | MRS2, magnesium transporter | |||||
Publication Statistics
PubMed Score 396.89
PubMed score by year
PubTator Score 34.74
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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