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Tbio
MRS2
Magnesium transporter MRS2 homolog, mitochondrial

Protein Summary
Description
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378353
  • ENSP00000367604
  • ENSG00000124532
  • ENST00000378386
  • ENSP00000367637
  • ENST00000443868
  • ENSP00000399585

Symbol
  • HPT
  • MRS2L
  • HPT
  • MRS2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
kinase perturbation
0.76
histone modification site profile
0.73
microRNA
0.73
cellular component
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.86   (req: < 5)
View Publications
Gene RIFs: 7   (req: <= 3)
View Gene RIFs
Antibodies: 53   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.86   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
24 targets
R-HSA-5223345
Reactome
Transport of small molecules
725 targets
R-HSA-382551
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
24 targets
R-HSA-5223345
Transport of small molecules
725 targets
R-HSA-382551
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
magnesium ion transmembrane transporter activity
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (75)
1 – 10 of 75
ZNF133
Tbio
Family: TF
Novelty: 0.17529215
p_int: 0.999954079
p_ni: 0.000045921
Data Source: BioPlex
SYP
Tbio
Novelty: 0.00030664
p_int: 0.997940383
p_ni: 0.002059617
Data Source: BioPlex
NOL9
Tdark
Family: Enzyme
Novelty: 0.06213937
p_int: 0.997923845
p_ni: 0.002076155
Score: 0.157
Data Source: BioPlex,STRINGDB
CHST8
Tbio
Family: Enzyme
Novelty: 0.03837088
p_int: 0.997443771
p_ni: 0.002556229
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.004102
p_int: 0.997019253
p_ni: 0.002980747
Data Source: BioPlex
TSPYL1
Tbio
Novelty: 0.09347181
p_int: 0.992321946
p_ni: 0.007678054
Data Source: BioPlex
TBC1D15
Tbio
Novelty: 0.2389305
p_int: 0.991373464
p_ni: 0.008626536
Data Source: BioPlex
MRPL35
Tdark
Novelty: 1.55555556
p_int: 0.990742502
p_ni: 0.009257498
Score: 0.157
Data Source: BioPlex,STRINGDB
SAP18
Tbio
Family: Enzyme
Novelty: 0.05845743
p_int: 0.989495947
p_ni: 0.010504053
Data Source: BioPlex
ZNF747
Tdark
p_int: 0.988470807
p_ni: 0.011529193
Data Source: BioPlex
Publication Statistics
PubMed Score  369.86

PubMed score by year
PubTator Score  34.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer