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Tbio
S100A14
Protein S100-A14

Protein Summary
Description
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344616
  • ENSP00000340463
  • ENSG00000189334
  • ENST00000368701
  • ENSP00000357690
  • ENST00000368702
  • ENSP00000357691
  • ENST00000476873
  • ENSP00000420296

Symbol
  • S100A15
  • BCMP84
  • S100A15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
PubMedID
0.72
biological process
0.63
transcription factor perturbation
0.61
cell type or tissue
0.51


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.57   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.57   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A14
VGNC:1645
457323
Mouse
MGI:1913416
66166
Dog
S100 calcium binding protein A14
VGNC:45826
612322
Horse
S100 calcium binding protein A14
VGNC:22650
100147656
Cow
S100 calcium binding protein A14
VGNC:34240
618250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A14
Mouse
Dog
S100 calcium binding protein A14
Horse
S100 calcium binding protein A14
Cow
S100 calcium binding protein A14
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HCY8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
p_int: 0.804723761
p_ni: 0.195276237
p_wrong: 3e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.779858377
p_ni: 0.220141623
Data Source: BioPlex
S100A16
Tbio
Novelty: 0.2386365
Score: 0.889
Data Source: STRINGDB
DLEC1
Tbio
Novelty: 0.0300128
Score: 0.711
Data Source: STRINGDB
RNF6
Tbio
Family: Enzyme
Novelty: 0.06214038
Score: 0.711
Data Source: STRINGDB
LZTS1
Tbio
Novelty: 0.02747372
Score: 0.647
Data Source: STRINGDB
NUCB1
Tchem
Novelty: 0.0040312
Score: 0.646
Data Source: STRINGDB
RAB25
Tbio
Family: Enzyme
Novelty: 0.01889483
Score: 0.644
Data Source: STRINGDB
S100A2
Tbio
Novelty: 0.00990471
Score: 0.62
Data Source: STRINGDB
S100A13
Tbio
Novelty: 0.0283577
Score: 0.595
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.57

PubMed score by year
PubTator Score  21.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer