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Tchem
TRPC7
Short transient receptor potential channel 7

Protein Summary
Description
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352189
  • ENSP00000330322
  • ENSG00000069018
  • ENST00000378459
  • ENSP00000367720
  • ENST00000513104
  • ENSP00000426070

Symbol
  • TRP7
  • TRP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
metabolite
0.82
cellular component
0.58
cell line
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.02   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.02   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
2
0
1.1
88.4
testosterone measurement
1
1
1
78.8
puberty onset measurement
1
1
1
50.4
body fat percentage
1
1
1
24.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
88.4
testosterone measurement
1
78.8
puberty onset measurement
1
50.4
body fat percentage
1
24.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 7
VGNC:7179
745732
Macaque
transient receptor potential cation channel subfamily C member 7
712863
Mouse
MGI:1349470
26946
Rat
RGD:628820
282822
Dog
transient receptor potential cation channel subfamily C member 7
VGNC:47872
481521
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 7
Macaque
transient receptor potential cation channel subfamily C member 7
Mouse
Rat
Dog
transient receptor potential cation channel subfamily C member 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCX4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Effects of PIP2 hydrolysis
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
G alpha (q) signalling events
Protein-Protein Interactions (41)
1 – 10 of 41
TRPC3
Tchem
Family: IC
Novelty: 0.00268752
p_int: 0.999957691
p_wrong: 0.000042309
Score: 0.93
Data Source: BioPlex,STRINGDB
TRPC6
Tchem
Family: IC
Novelty: 0.00118598
Score: 0.931
Data Source: STRINGDB
TRPC1
Tbio
Family: IC
Novelty: 0.00233677
Score: 0.91
Data Source: Reactome,STRINGDB
TRPC4
Tchem
Family: IC
Novelty: 0.00339889
Score: 0.909
Data Source: Reactome,STRINGDB
TRPC5
Tchem
Family: IC
Novelty: 0.00406517
Score: 0.908
Data Source: Reactome,STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.905
Data Source: STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.903
Data Source: STRINGDB
TXNDC17
Tbio
Novelty: 0.0142537
Score: 0.786
Data Source: STRINGDB
TACR1
Tclin
Family: GPCR
Novelty: 0.00062762
Score: 0.713
Data Source: STRINGDB
GNRH2
Tbio
Novelty: 0.0027348
Score: 0.709
Data Source: STRINGDB
Publication Statistics
PubMed Score  213.02

PubMed score by year
PubTator Score  82.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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