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Tbio
ZNF304
Zinc finger protein 304

Protein Summary
Description
Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282286
  • ENSP00000282286
  • ENSG00000131845
  • ENST00000391705
  • ENSP00000375586
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
cell line
0.71
microRNA
0.61
protein domain
0.58
histone modification site profile
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 304 [Source:HGNC Symbol;Acc:HGNC:13505]
Dog
zinc finger protein 304
476369
Horse
zinc finger protein 304
VGNC:52465
100060050
Cow
zinc finger protein 304
VGNC:52852
526123
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 304 [Source:HGNC Symbol;Acc:HGNC:13505]
Dog
zinc finger protein 304
Horse
zinc finger protein 304
Cow
zinc finger protein 304
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCX3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (10)
1 – 10 of 10
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.935
Data Source: STRINGDB
USP28
Tbio
Family: Enzyme
Novelty: 0.02432294
Score: 0.67
Data Source: STRINGDB
MAFG
Tbio
Family: TF
Novelty: 0.01605125
Score: 0.473
Data Source: STRINGDB
ZBED5
Tdark
Novelty: 0.47929262
Score: 0.441
Data Source: STRINGDB
VIM
Tbio
Novelty: 0.00030317
Score: 0.438
Data Source: STRINGDB
CHST10
Tbio
Family: Enzyme
Novelty: 0.06829376
Score: 0.435
Data Source: STRINGDB
QKI
Tbio
Novelty: 0.00966983
Score: 0.429
Data Source: STRINGDB
PCDHGA4
Tdark
Novelty: 0.95863389
Score: 0.426
Data Source: STRINGDB
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
Score: 0.424
Data Source: STRINGDB
STK33
Tchem
Family: Kinase
Novelty: 0.05051872
Score: 0.415
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.95

PubMed score by year
PubTator Score  2.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer