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Tbio
BRMS1
Breast cancer metastasis-suppressor 1

Protein Summary
Description
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359957
  • ENSP00000353042
  • ENSG00000174744
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
biological process
0.8
transcription factor binding site profile
0.8
hub protein
0.79
biological term
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.96   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.96   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDACs deacetylate histones
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (114)
1 – 10 of 114
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.999999955
p_ni: 4.4e-8
p_wrong: 1e-9
Score: 0.773
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999994459
p_ni: 0.000005541
Score: 0.958
Data Source: BioPlex,STRINGDB
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
p_int: 0.999987618
p_ni: 0.00001238
p_wrong: 2e-9
Score: 0.962
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999942451
p_ni: 0.000057549
Score: 0.97
Data Source: BioPlex,STRINGDB
PRPS1
Tbio
Family: Kinase
Novelty: 0.01139656
p_int: 0.989927412
p_ni: 0.004853077
p_wrong: 0.005219511
Score: 0.177
Data Source: BioPlex,STRINGDB
MXD1
Tbio
Family: TF
Novelty: 0.0353468
p_int: 0.983869019
p_ni: 0.015204242
p_wrong: 0.000926738
Score: 0.226
Data Source: BioPlex,STRINGDB
MXD3
Tbio
Family: TF
Novelty: 0.07436584
p_int: 0.979573981
p_ni: 0.020425962
p_wrong: 5.7e-8
Score: 0.321
Data Source: BioPlex,STRINGDB
MBIP
Tbio
Novelty: 0.05807454
p_int: 0.975108932
p_ni: 0.023463564
p_wrong: 0.001427504
Data Source: BioPlex
ZNF704
Tdark
Novelty: 0.34442716
p_int: 0.95499286
p_ni: 0.044778847
p_wrong: 0.000228293
Score: 0.547
Data Source: BioPlex,STRINGDB
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.907593762
p_ni: 0.08303356
p_wrong: 0.009372678
Data Source: BioPlex
Publication Statistics
PubMed Score  71.96

PubMed score by year
PubTator Score  96.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer