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Tdark
POLD4
DNA polymerase delta subunit 4

Protein Summary
Description
As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480). This gene encodes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312419
  • ENSP00000311368
  • ENSG00000175482
  • ENST00000539074
  • ENSP00000444780

Symbol
  • POLDS
  • p12
  • POLDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
histone modification site profile
0.72
pathway
0.7
disease perturbation
0.68
transcription factor perturbation
0.68


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase delta 4, accessory subunit
VGNC:48939
451366
Mouse
MGI:1916995
69745
Rat
RGD:1308519
361698
Dog
DNA polymerase delta 4, accessory subunit
611847
Horse
DNA polymerase delta 4, accessory subunit
100059111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase delta 4, accessory subunit
Mouse
Rat
Dog
DNA polymerase delta 4, accessory subunit
Horse
DNA polymerase delta 4, accessory subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCU8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (60)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 41
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Damage Bypass
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Damage Bypass
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (143)
1 – 10 of 143
POLD2
Tbio
Family: Enzyme
Novelty: 0.05932998
p_int: 0.999998777
p_ni: 1e-9
p_wrong: 0.000001222
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
POLD3
Tbio
Family: Enzyme
Novelty: 0.02646621
Score: 0.998
Data Source: Reactome,STRINGDB
POLD1
Tclin
Family: Enzyme
Novelty: 0.00508209
Score: 0.997
Data Source: Reactome,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.974
Data Source: Reactome,STRINGDB
POLE
Tclin
Family: Enzyme
Novelty: 0.00371129
Score: 0.971
Data Source: STRINGDB
LIG1
Tchem
Family: Enzyme
Novelty: 0.00326816
Score: 0.963
Data Source: Reactome,STRINGDB
POLE2
Tbio
Family: Enzyme
Novelty: 0.03129531
Score: 0.955
Data Source: STRINGDB
POLA1
Tclin
Family: Enzyme
Novelty: 0.0039096
Score: 0.949
Data Source: Reactome,STRINGDB
DTL
Tbio
Novelty: 0.01659105
Score: 0.943
Data Source: Reactome,STRINGDB
POLE4
Tdark
Family: Enzyme
Novelty: 0.23346084
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.34

PubMed score by year
PubTator Score  13.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer