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Tbio
CELSR2
Cadherin EGF LAG seven-pass G-type receptor 2

Protein Summary
Description
Receptor that may have an important role in cell/cell signaling during nervous system formation. The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271332
  • ENSP00000271332
  • ENSG00000143126

Symbol
  • CDHF10
  • EGFL2
  • KIAA0279
  • MEGF3
  • EGFL2
  • MEGF3
  • ADGRC2
  • CDHF10
  • Flamingo1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
disease perturbation
0.95
kinase perturbation
0.81
PubMedID
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.16   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.16   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.99973697
p_ni:  0.00026303
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.999725945
p_ni:  0.000274055
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999211881
p_ni:  0.000788119
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.998989188
p_ni:  0.001010812
Score:  0.489
Data Source:  BioPlex,STRINGDB
PCDH12
Tbio
Novelty:  0.06268895
p_int:  0.985194746
p_ni:  0.014805247
p_wrong:  7e-9
Data Source:  BioPlex
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.98354445
p_ni:  0.01645555
Data Source:  BioPlex
CC2D1B
Tbio
Novelty:  0.22031767
p_int:  0.982868218
p_ni:  0.017131782
Data Source:  BioPlex
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.98090449
p_ni:  0.019095486
p_wrong:  2.4e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
FBXO10
Tbio
Novelty:  0.18324932
p_int:  0.979624252
p_ni:  0.020375748
Score:  0.156
Data Source:  BioPlex,STRINGDB
LAG3
Tbio
Novelty:  0.00187736
p_int:  0.974429394
p_ni:  0.025570605
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
27
29
66
5.5
99.9
apolipoprotein B measurement
3
23
25
99.9
total cholesterol measurement
16
21
49
6.2
99.9
apolipoprotein A 1 measurement
3
5
5
98.3
13
6
4
1.1
98.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
66
5.5
99.9
apolipoprotein B measurement
25
99.9
total cholesterol measurement
49
6.2
99.9
apolipoprotein A 1 measurement
5
98.3
4
1.1
98.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin EGF LAG seven-pass G-type receptor 2
VGNC:7360
457086
Macaque
cadherin EGF LAG seven-pass G-type receptor 2
700893
Mouse
MGI:1858235
53883
Rat
RGD:69237
83465
Dog
cadherin EGF LAG seven-pass G-type receptor 2
VGNC:39098
479916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin EGF LAG seven-pass G-type receptor 2
Macaque
cadherin EGF LAG seven-pass G-type receptor 2
Mouse
Rat
Dog
cadherin EGF LAG seven-pass G-type receptor 2
Publication Statistics
PubMed Score 36.16
PubMed score by year
PubTator Score 17.56
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title