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Tbio
FGF22
Fibroblast growth factor 22

Protein Summary
Description
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215530
  • ENSP00000215530
  • ENSG00000070388
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
histone modification site profile
0.61
tissue sample
0.61
pathway
0.59
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
Score:  0.979
Data Source:  STRINGDB
FGFBP1
Tbio
Novelty:  0.02117534
Score:  0.968
Data Source:  Reactome,STRINGDB
FGF18
Tbio
Novelty:  0.00802997
Score:  0.957
Data Source:  STRINGDB
FGF23
Tclin
Novelty:  0.00047318
Score:  0.955
Data Source:  STRINGDB
FGFRL1
Tbio
Novelty:  0.02178846
Score:  0.945
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.938
Data Source:  STRINGDB
FRS2
Tbio
Novelty:  0.00654052
Score:  0.933
Data Source:  STRINGDB
FGFBP2
Tbio
Novelty:  0.17105915
Score:  0.932
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.923
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
1 – 5 of 18
FLT4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
KIT
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
PDGFRB
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  7
more:  3 more common pathways
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
Pathways (103)
Activated point mutants of FGFR2 (R-HSA-2033519)

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Find Similar Targets
Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
2
1
5.8
55.9
corneal resistance factor
1
1
1
44.7
prostate cancer
1
1
0
1.9
38.6
disease progression measurement
1
1
0
1.9
38.6
cognitive function measurement
2
1
2
36.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
5.8
55.9
corneal resistance factor
1
44.7
prostate cancer
0
1.9
38.6
disease progression measurement
0
1.9
38.6
cognitive function measurement
2
36.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor 22
702727
Mouse
MGI:1914362
67112
Rat
RGD:620177
170579
Dog
fibroblast growth factor 22
VGNC:40849
612404
Cow
fibroblast growth factor 22
VGNC:52233
519657
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor 22
Mouse
Rat
Dog
fibroblast growth factor 22
Cow
fibroblast growth factor 22
Publication Statistics
PubMed Score 24.90
PubMed score by year
PubTator Score 7.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title