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Tbio
XAB2
Pre-mRNA-splicing factor SYF1

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358368
  • ENSP00000351137
  • ENSG00000076924

Symbol
  • HCNP
  • KIAA1177
  • SYF1
  • HCNP
  • HCRN
  • SYF1
  • NTC90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor
0.77
interacting protein
0.75
transcription factor binding site profile
0.75
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (387)
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.999982902
p_ni:  0.000017098
Score:  0.998
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999958848
p_ni:  0.000041152
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999953196
p_ni:  0.000046804
Score:  0.999
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.999894156
p_ni:  0.000105843
Score:  0.653
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999860482
p_ni:  0.000139518
Score:  0.575
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999721555
p_ni:  0.000278445
Score:  0.996
Data Source:  BioPlex,STRINGDB
SYF2
Tbio
Novelty:  0.06114903
p_int:  0.999709524
p_ni:  0.000290476
Score:  0.999
Data Source:  BioPlex,STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
p_int:  0.999260189
p_ni:  0.000739811
Score:  0.205
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.998952307
p_ni:  0.001047693
Score:  0.912
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.998766041
p_ni:  0.001233958
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resistin measurement
1
2
0
6.2
91.1
mean platelet volume
1
1
1
53.7
opioid overdose severity measurement
1
1
1
31.4
neutrophil count
1
1
1
13.4
monocyte percentage of leukocytes
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resistin measurement
0
6.2
91.1
mean platelet volume
1
53.7
opioid overdose severity measurement
1
31.4
neutrophil count
1
13.4
monocyte percentage of leukocytes
1
10.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
XPA binding protein 2
VGNC:2199
468695
Macaque
XPA binding protein 2
704109
Mouse
MGI:1914689
67439
Rat
RGD:621217
245976
Dog
XPA binding protein 2
VGNC:48445
484995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
XPA binding protein 2
Macaque
XPA binding protein 2
Mouse
Rat
Dog
XPA binding protein 2
Publication Statistics
PubMed Score 23.69
PubMed score by year
PubTator Score 13.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title