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Tbio
TCF7L1
Transcription factor 7-like 1

Protein Summary
Description
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282111
  • ENSP00000282111
  • ENSG00000152284

Symbol
  • TCF3
  • TCF3
  • TCF-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.86
trait
0.75
protein domain
0.73
pathway
0.72
phenotype
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.6   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.6   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.99
Data Source:  Reactome,STRINGDB
AXIN2
Tchem
Novelty:  0.00273189
Score:  0.956
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.956
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.956
Data Source:  STRINGDB
TLE3
Tbio
Novelty:  0.02641884
Score:  0.955
Data Source:  STRINGDB
TLE2
Tbio
Novelty:  0.03922169
Score:  0.953
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.953
Data Source:  STRINGDB
TLE1
Tbio
Novelty:  0.00594261
Score:  0.952
Data Source:  STRINGDB
NLK
Tchem
Family:  Kinase
Novelty:  0.01512201
Score:  0.951
Data Source:  STRINGDB
TLE4
Tbio
Novelty:  0.02094922
Score:  0.949
Data Source:  STRINGDB
Pathways (91)
Beta-catenin independent WNT signaling (R-HSA-3858494)

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1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
68.5
high density lipoprotein cholesterol measurement
2
2
3
59.7
aspartate aminotransferase measurement
1
1
0
7.4
59
bone density
1
2
2
39.4
neutrophil count
2
1
2
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
68.5
high density lipoprotein cholesterol measurement
3
59.7
aspartate aminotransferase measurement
0
7.4
59
bone density
2
39.4
neutrophil count
2
34.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor 7 like 1
VGNC:10780
744526
Macaque
transcription factor 7 like 1
694560
Mouse
MGI:1202876
21415
Rat
RGD:1311671
312451
Dog
transcription factor 7 like 1
VGNC:47199
612070
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor 7 like 1
Macaque
transcription factor 7 like 1
Mouse
Rat
Dog
transcription factor 7 like 1
Publication Statistics
PubMed Score 29.60
PubMed score by year
PubTator Score 16.22
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title