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Tbio
CYP4F12
Cytochrome P450 4F12

Protein Summary
Description
Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324632
  • ENSP00000321821
  • ENSG00000186204
  • ENST00000517734
  • ENSP00000430849
  • ENST00000548435
  • ENSP00000449703
  • ENST00000550308
  • ENSP00000448998

Symbol
  • CYPIVF12
  • F22329_1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
biological process
0.77
PubMedID
0.7
pathway
0.68
cellular component
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.49   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.49   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
CYP4F2
Tchem
Family:  Enzyme
Novelty:  0.0050361
p_int:  1
Score:  0.729
Data Source:  BioPlex,STRINGDB
CYP4F8
Tbio
Novelty:  0.06814051
p_int:  1
Score:  0.692
Data Source:  BioPlex,STRINGDB
ZBTB18
Tbio
Family:  TF
Novelty:  0.03802355
p_int:  0.999986283
p_ni:  0.000013469
p_wrong:  2.48e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  0.813581302
p_ni:  0.000671432
p_wrong:  0.185747266
Score:  0.187
Data Source:  BioPlex,STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.693
Data Source:  STRINGDB
PPIG
Tchem
Family:  Enzyme
Novelty:  0.00014569
Score:  0.538
Data Source:  STRINGDB
FMO5
Tbio
Family:  Enzyme
Novelty:  0.05610368
Score:  0.493
Data Source:  STRINGDB
FMO1
Tbio
Family:  Enzyme
Novelty:  0.02090294
Score:  0.477
Data Source:  STRINGDB
CYP2J2
Tchem
Novelty:  0.00534181
Score:  0.46
Data Source:  STRINGDB
UGT1A6
Tbio
Family:  Enzyme
Novelty:  0.00146917
Score:  0.456
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Eicosanoids
Reactome
Fatty acids
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Eicosanoids
Fatty acids
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
40.1
total cholesterol measurement
1
1
1
22.8
lymphocyte count
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
40.1
total cholesterol measurement
1
22.8
lymphocyte count
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily F member 12
VGNC:7473
468754
Cow
phylloquinone omega-hydroxylase CYP4F2
100295883
Xenopus
cytochrome P450 family 4 subfamily F member 2
XB-GENE-6258041
548774
Zebrafish
ZDB-GENE-070410-108
100037390
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily F member 12
Cow
phylloquinone omega-hydroxylase CYP4F2
Xenopus
cytochrome P450 family 4 subfamily F member 2
Zebrafish
Publication Statistics
PubMed Score 17.49
PubMed score by year
PubTator Score 12.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title