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Tchem
PDE11A
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Protein Summary
Description
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286063
  • ENSP00000286063
  • ENSG00000128655
  • ENST00000389683
  • ENSP00000374333
  • ENST00000409504
  • ENSP00000386539

Symbol
  • PPNAD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
virus perturbation
0.94
trait
0.93
cell type or tissue
0.88
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.46   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.46   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 78
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (78)
CHEMBL4128481
Rendered image for CHEMBL4128481
CHEMBL4218772
Rendered image for CHEMBL4218772
CHEMBL4284354
Rendered image for CHEMBL4284354
CHEMBL4278921
Rendered image for CHEMBL4278921
CHEMBL4282274
Rendered image for CHEMBL4282274
CHEMBL3742354
Rendered image for CHEMBL3742354
CHEMBL4067682
Rendered image for CHEMBL4067682
CHEMBL4283606
Rendered image for CHEMBL4283606
CHEMBL2431826
Rendered image for CHEMBL2431826
CHEMBL567470
Rendered image for CHEMBL567470
Protein-Protein Interactions (105)
TTC30B
Tbio
Novelty:  0.10944566
Score:  0.914
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.906
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.905
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.904
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.904
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.903
Data Source:  STRINGDB
PDE6G
Tclin
Family:  Enzyme
Novelty:  0.03113994
Score:  0.828
Data Source:  STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
Score:  0.817
Data Source:  STRINGDB
GUCY1A2
Tclin
Family:  Enzyme
Novelty:  0.05335767
Score:  0.806
Data Source:  STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.804
Data Source:  STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 5
NPR1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
GUCY1A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY1B1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY2C
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
GUCY1A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (21)
G alpha (s) signalling events (R-HSA-418555)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Hemostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 11A
VGNC:2748
740616
Mouse
MGI:3036251
241489
Dog
phosphodiesterase 11A
VGNC:44346
488422
Cow
phosphodiesterase 11A
VGNC:32669
524446
Xenopus
phosphodiesterase 11A
XB-GENE-5999893
100379882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 11A
Mouse
Dog
phosphodiesterase 11A
Cow
phosphodiesterase 11A
Xenopus
phosphodiesterase 11A
Publication Statistics
PubMed Score 50.46
PubMed score by year
PubTator Score 39.70
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title