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Tchem
PDE11A
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Protein Summary
Description
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286063
  • ENSP00000286063
  • ENSG00000128655
  • ENST00000389683
  • ENSP00000374333
  • ENST00000409504
  • ENSP00000386539

Symbol
  • PPNAD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
virus perturbation
0.94
trait
0.93
cell type or tissue
0.88
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.43   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.43   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
8.2
96
Myopia
3
3
0
1.2
80.6
smoking status measurement
1
1
1
67.9
self reported educational attainment
1
1
1
56.3
age at onset
1
1
0
8.2
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
8.2
96
Myopia
0
1.2
80.6
smoking status measurement
1
67.9
self reported educational attainment
1
56.3
age at onset
0
8.2
55.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 11A
VGNC:2748
740616
Mouse
MGI:3036251
241489
Dog
phosphodiesterase 11A
VGNC:44346
488422
Cow
phosphodiesterase 11A
VGNC:32669
524446
Xenopus
phosphodiesterase 11A
XB-GENE-5999893
100379882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 11A
Mouse
Dog
phosphodiesterase 11A
Cow
phosphodiesterase 11A
Xenopus
phosphodiesterase 11A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCR9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Hemostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (105)
1 – 10 of 105
TTC30B
Tbio
Novelty: 0.10944566
Score: 0.914
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.906
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.905
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.904
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.904
Data Source: STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.903
Data Source: STRINGDB
PDE6G
Tclin
Family: Enzyme
Novelty: 0.03113994
Score: 0.828
Data Source: STRINGDB
PRKAR1A
Tbio
Family: Enzyme
Novelty: 0.00311432
Score: 0.817
Data Source: STRINGDB
GUCY1A2
Tclin
Family: Enzyme
Novelty: 0.05335767
Score: 0.806
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.804
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.43

PubMed score by year
PubTator Score  39.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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