Tdark NPVF Pro-FMRFamide-related neuropeptide VF

Protein Summary

Description

Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia.

Uniprot Accession IDs

• Q9HCQ7
• A4D164
• Q7LE27
• Q96PI9

Gene Name

• NPVF

Ensembl ID

• ENST00000222674
• ENSP00000222674
• ENSG00000105954

Symbol

• C7orf9
• RFRP
• RFRP
• C7orf9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.6
cell type or tissue	0.54
gene perturbation	0.51
transcription factor	0.47
metabolite	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.92   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.92   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0