Tchem GP6 Platelet glycoprotein VI

Protein Summary

Description

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9HCN6
• Q9HCN7
• Q9UIF2
• GPVI

Gene Name

• GP6

Ensembl ID

• ENST00000310373
• ENSP00000308782
• ENSG00000088053
• ENST00000333884
• ENSP00000334552
• ENST00000417454
• ENSP00000394922
• ENST00000612184
• ENSP00000479873
• ENSG00000277439
• ENST00000616456
• ENSP00000483314
• ENST00000622279
• ENSP00000484029

Symbol

• GPIV
• GPVI
• BDPLT11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.93
cellular component	0.79
disease	0.78
cell type or tissue	0.75
tissue sample	0.59

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Platelet Glycoprotein Vi

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Platelet Glycoprotein Vi

Protein / ... / Protease Inhibitor / Platelet Glycoprotein Vi

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Platelet Glycoprotein Vi

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.79   (req: < 5)

Gene RIFs: 183   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.79   (req: >= 5)

Gene RIFs: 183   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3