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Tbio
GPN1
GPN-loop GTPase 1

Protein Summary
Description
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264718
  • ENSP00000264718
  • ENSG00000198522
  • ENST00000407583
  • ENSP00000384255
  • ENST00000424214
  • ENSP00000398115
  • ENST00000458167
  • ENSP00000412170
  • ENST00000503738
  • ENSP00000427269
  • ENST00000515877
  • ENSP00000424678
  • ENST00000610189
  • ENSP00000476446
  • ENST00000616939
  • ENSP00000484680

Symbol
  • MBDIN
  • RPAP4
  • XAB1
  • XAB1
  • MBDIN
  • NTPBP
  • RPAP4
  • ATPBD1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
molecular function
0.91
histone modification site profile
0.84
transcription factor perturbation
0.8
transcription factor binding site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.16   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.16   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
59.5
metabolic syndrome
1
1
1
44.8
triglyceride measurement
1
1
1
44.8
oral cavity cancer
1
1
0
1.2
26.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
59.5
metabolic syndrome
1
44.8
triglyceride measurement
1
44.8
oral cavity cancer
0
1.2
26.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GPN-loop GTPase 1
VGNC:263
470341
Macaque
GPN-loop GTPase 1
701903
Mouse
MGI:1921504
74254
Rat
RGD:1589985
688393
Dog
GPN-loop GTPase 1-like
608308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GPN-loop GTPase 1
Macaque
GPN-loop GTPase 1
Mouse
Rat
Dog
GPN-loop GTPase 1-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCN4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (102)
1 – 10 of 102
TMEM183A
Tdark
Novelty: 0.4017284
p_int: 0.999999742
p_ni: 2.35e-7
p_wrong: 2.3e-8
Data Source: BioPlex
POLR3K
Tbio
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999920163
p_ni: 0.000078365
p_wrong: 0.000001472
Score: 0.183
Data Source: BioPlex,STRINGDB
RPAP2
Tbio
Family: Enzyme
Novelty: 0.03383659
p_int: 0.999889175
p_ni: 0.000110825
Score: 0.941
Data Source: BioPlex,STRINGDB
POLR3E
Tbio
Family: Enzyme
Novelty: 0.06500715
p_int: 0.999825078
p_ni: 0.000174922
Score: 0.196
Data Source: BioPlex,STRINGDB
POLR3D
Tbio
Family: Enzyme
Novelty: 0.02616321
p_int: 0.999734888
p_ni: 0.000265046
p_wrong: 6.6e-8
Score: 0.331
Data Source: BioPlex,STRINGDB
RPAP1
Tdark
Family: Enzyme
Novelty: 0.23737405
p_int: 0.99970116
p_ni: 0.00029884
Score: 0.942
Data Source: BioPlex,STRINGDB
CRCP
Tbio
Family: Enzyme
Novelty: 0.01111812
p_int: 0.999527713
p_ni: 0.000467295
p_wrong: 0.000004992
Data Source: BioPlex
POLR3H
Tbio
Family: Enzyme
Novelty: 0.16483597
p_int: 0.999343958
p_ni: 0.000655927
p_wrong: 1.15e-7
Score: 0.277
Data Source: BioPlex,STRINGDB
POLR3B
Tbio
Family: Enzyme
Novelty: 0.02526167
p_int: 0.998836138
p_ni: 0.001163862
Score: 0.436
Data Source: BioPlex,STRINGDB
POLR2M
Tbio
Family: Enzyme
Novelty: 0.11413088
p_int: 0.997350195
p_ni: 0.00264975
p_wrong: 5.6e-8
Score: 0.822
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.16

PubMed score by year
PubTator Score  11.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer