TRIM39
E3 ubiquitin-protein ligase TRIM39
Protein Summary
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000376656
- ENSP00000365844
- ENSG00000204599
- ENST00000376659
- ENSP00000365847
- ENST00000383601
- ENSP00000373095
- ENSG00000206495
- ENST00000383602
- ENSP00000373096
- ENST00000383603
- ENSP00000373097
- ENST00000396547
- ENSP00000379796
- ENST00000396548
- ENSP00000379797
- ENST00000396551
- ENSP00000379800
- ENST00000400644
- ENSP00000383486
- ENST00000413715
- ENSP00000411949
- ENSG00000224994
- ENST00000414015
- ENSP00000401071
- ENST00000419790
- ENSP00000401184
- ENSG00000229929
- ENST00000424575
- ENSP00000409902
- ENSG00000230308
- ENST00000426469
- ENSP00000397043
- ENST00000430502
- ENSP00000398956
- ENSG00000232839
- ENST00000431272
- ENSP00000396986
- ENST00000433900
- ENSP00000389852
- ENST00000438076
- ENSP00000389198
- ENST00000438859
- ENSP00000411582
- ENSG00000226437
- ENST00000440117
- ENSP00000392130
- ENST00000443109
- ENSP00000414525
- ENST00000445206
- ENSP00000391917
- ENST00000446397
- ENSP00000412743
- ENST00000449318
- ENSP00000404904
- ENST00000450778
- ENSP00000387445
- ENST00000451132
- ENSP00000394353
- ENST00000451715
- ENSP00000398355
- ENST00000452705
- ENSP00000415259
- ENST00000458607
- ENSP00000404340
- ENST00000547030
- ENSP00000449847
- ENST00000548002
- ENSP00000447835
- ENST00000549841
- ENSP00000448572
- ENST00000550282
- ENSP00000449272
- ENST00000552337
- ENSP00000450288
- ENST00000552520
- ENSP00000448462
- RNF23
- TFP
- TFP
- RNF23
- TRIM39B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
interacting protein | 0.67 | ||
protein complex | 0.66 | ||
tissue sample | 0.64 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.42 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 255 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.42 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 255 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0