You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KIAA1549
UPF0606 protein KIAA1549

Protein Summary
Description
The protein encoded by this gene belongs to the UPF0606 family. This gene has been found to be fused to the BRAF oncogene in many cases of pilocytic astrocytoma. The fusion results from 2Mb tandem duplications at 7q34. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
virus perturbation
0.83
microRNA
0.77
transcription factor perturbation
0.74
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.16   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.16   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
85
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Protein-Protein Interactions (108)
1 – 10 of 108
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999999939
p_ni: 3e-8
p_wrong: 3.1e-8
Data Source: BioPlex
OR10A4
Tbio
Family: oGPCR
Novelty: 0.0796753
p_int: 0.999999732
p_ni: 2.68e-7
Data Source: BioPlex
CRTC3
Tbio
Novelty: 0.04041516
p_int: 0.999998843
p_ni: 0.000001157
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999998723
p_ni: 3e-9
p_wrong: 0.000001274
Score: 0.251
Data Source: BioPlex,STRINGDB
OR6B1
Tdark
Family: oGPCR
Novelty: 1.63220691
p_int: 0.999987873
p_ni: 0.000012127
Data Source: BioPlex
OR51E1
Tbio
Family: oGPCR
Novelty: 0.05230721
p_int: 0.999985584
p_ni: 0.000014416
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999964994
p_ni: 0.000030487
p_wrong: 0.000004518
Score: 0.239
Data Source: BioPlex,STRINGDB
SERPINA12
Tbio
Novelty: 0.00549132
p_int: 0.999959661
p_ni: 0.000037591
p_wrong: 0.000002749
Data Source: BioPlex
OR6A2
Tdark
Family: oGPCR
Novelty: 0.08554292
p_int: 0.999917645
p_ni: 0.000082355
Data Source: BioPlex
SLC5A7
Tchem
Family: Transporter
Novelty: 0.00232251
p_int: 0.999582515
p_ni: 0.000417485
Data Source: BioPlex
Publication Statistics
PubMed Score  84.16

PubMed score by year
PubTator Score  39.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: