Tbio PLXNA4 Plexin-A4

Protein Summary

Description

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Uniprot Accession IDs

• Q9HCM2
• A4D1N6
• E9PAM2
• Q6UWC6
• Q6ZW89
• Q8N969
• Q8ND00
• Q8NEN3
• Q9NTD4

Gene Name

• PLXNA4

Ensembl ID

• ENST00000321063
• ENSP00000323194
• ENSG00000221866
• ENST00000359827
• ENSP00000352882
• ENST00000378539
• ENSP00000367800
• ENST00000423507
• ENSP00000392772

Symbol

• KIAA1550
• PLXNA4A
• PLXNA4B
• PLEXA4
• PLXNA4A
• PLXNA4B
• FAYV2820
• PRO34003

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
trait	0.97
microRNA	0.82
phenotype	0.73
transcription factor	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.42   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.42   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0