Protein Summary
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
- ENST00000321063
- ENSP00000323194
- ENSG00000221866
- ENST00000359827
- ENSP00000352882
- ENST00000378539
- ENSP00000367800
- ENST00000423507
- ENSP00000392772
- KIAA1550
- PLXNA4A
- PLXNA4B
- PLEXA4
- PLXNA4A
- PLXNA4B
- FAYV2820
- PRO34003
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
trait | 0.97 | ||
microRNA | 0.82 | ||
phenotype | 0.73 | ||
transcription factor | 0.72 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.2 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.2 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 1 | 3 | 86 | |||||
smoking status measurement | 1 | 2 | 2 | 69.1 | |||||
cognitive function measurement | 1 | 1 | 1 | 66.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 61.5 | |||||
smoking behaviour measurement | 1 | 1 | 1 | 53.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 86 | |||||
smoking status measurement | 2 | 69.1 | |||||
cognitive function measurement | 1 | 66.7 | |||||
self reported educational attainment | 1 | 61.5 | |||||
smoking behaviour measurement | 1 | 53.5 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | plexin A4 | VGNC:4471 | 463737 | |||||
Macaque | plexin A4 | 705098 | ||||||
Mouse | MGI:2179061 | 243743 | ||||||
Rat | RGD:1308074 | 312213 | ||||||
Dog | plexin A4 | VGNC:44721 | 482251 | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (13)
Reactome (12)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | CRMPs in Sema3A signaling | ||||
Reactome | Developmental Biology | ||||
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
CRMPs in Sema3A signaling | ||||
Developmental Biology | ||||
FOXO-mediated transcription | ||||
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Gene Ontology Terms (21)
Functions (1)
Components (3)
Processes (17)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (118)
1 – 10 of 118
CRYZL1
Family: Enzyme
Novelty: 0.04435286
p_int: 0.999999303
p_ni: 4.12e-7
p_wrong: 2.85e-7
Score: 0.29
Data Source: BioPlex,STRINGDB
DCT
Family: Enzyme
Novelty: 0.00411451
p_int: 0.993305066
p_ni: 0.006678968
p_wrong: 0.000015966
Score: 0.481
Data Source: BioPlex,STRINGDB
DNAAF2
Novelty: 0.01254416
p_int: 0.780867088
p_ni: 0.001920056
p_wrong: 0.217212856
Score: 0.183
Data Source: BioPlex,STRINGDB
SEMA6A
Novelty: 0.00624456
Score: 0.995
Data Source: Reactome,STRINGDB
SEMA3A
Novelty: 0.00167362
Score: 0.993
Data Source: Reactome,STRINGDB
NRP1
Novelty: 0.00153628
Score: 0.977
Data Source: Reactome,STRINGDB
SEMA3G
Novelty: 0.0107653
Score: 0.966
Data Source: STRINGDB
SEMA3E
Novelty: 0.00936004
Score: 0.965
Data Source: STRINGDB
SEMA3B
Novelty: 0.00626976
Score: 0.964
Data Source: STRINGDB
SEMA3D
Novelty: 0.00821843
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score 49.20
PubMed score by year
PubTator Score 13.39
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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