You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PLXNA4
Plexin-A4

Protein Summary
Description
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321063
  • ENSP00000323194
  • ENSG00000221866
  • ENST00000359827
  • ENSP00000352882
  • ENST00000378539
  • ENSP00000367800
  • ENST00000423507
  • ENSP00000392772

Symbol
  • KIAA1550
  • PLXNA4A
  • PLXNA4B
  • PLEXA4
  • PLXNA4A
  • PLXNA4B
  • FAYV2820
  • PRO34003
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.97
microRNA
0.82
phenotype
0.73
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.2   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.2   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
86
smoking status measurement
1
2
2
69.1
cognitive function measurement
1
1
1
66.7
self reported educational attainment
1
1
1
61.5
smoking behaviour measurement
1
1
1
53.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
86
smoking status measurement
2
69.1
cognitive function measurement
1
66.7
self reported educational attainment
1
61.5
smoking behaviour measurement
1
53.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plexin A4
VGNC:4471
463737
Macaque
plexin A4
705098
Mouse
MGI:2179061
243743
Rat
RGD:1308074
312213
Dog
plexin A4
VGNC:44721
482251
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plexin A4
Macaque
plexin A4
Mouse
Rat
Dog
plexin A4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (118)
1 – 10 of 118
CRYZL1
Tbio
Family: Enzyme
Novelty: 0.04435286
p_int: 0.999999303
p_ni: 4.12e-7
p_wrong: 2.85e-7
Score: 0.29
Data Source: BioPlex,STRINGDB
DCT
Tbio
Family: Enzyme
Novelty: 0.00411451
p_int: 0.993305066
p_ni: 0.006678968
p_wrong: 0.000015966
Score: 0.481
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.780867088
p_ni: 0.001920056
p_wrong: 0.217212856
Score: 0.183
Data Source: BioPlex,STRINGDB
SEMA6A
Tbio
Novelty: 0.00624456
Score: 0.995
Data Source: Reactome,STRINGDB
SEMA3A
Tbio
Novelty: 0.00167362
Score: 0.993
Data Source: Reactome,STRINGDB
NRP1
Tchem
Novelty: 0.00153628
Score: 0.977
Data Source: Reactome,STRINGDB
SEMA3G
Tbio
Novelty: 0.0107653
Score: 0.966
Data Source: STRINGDB
SEMA3E
Tbio
Novelty: 0.00936004
Score: 0.965
Data Source: STRINGDB
SEMA3B
Tbio
Novelty: 0.00626976
Score: 0.964
Data Source: STRINGDB
SEMA3D
Tbio
Novelty: 0.00821843
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.20

PubMed score by year
PubTator Score  13.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: