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Tbio
CHD8
Chromodomain-helicase-DNA-binding protein 8

Protein Summary
Description
DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399982
  • ENSP00000382863
  • ENSG00000100888
  • ENST00000430710
  • ENSP00000406288
  • ENST00000557364
  • ENSP00000451601
  • ENST00000643469
  • ENSP00000495070
  • ENST00000645929
  • ENSP00000494402
  • ENST00000646647
  • ENSP00000495240

Symbol
  • HELSNF1
  • KIAA1564
  • AUTS18
  • HELSNF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
disease perturbation
0.96
interacting protein
0.91
biological process
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.77   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.77   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
77.9
self reported educational attainment
1
1
1
59
BMI-adjusted hip circumference
1
1
1
47.7
mathematical ability
1
1
1
35
smoking status measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
77.9
self reported educational attainment
1
59
BMI-adjusted hip circumference
1
47.7
mathematical ability
1
35
smoking status measurement
1
15.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 8
VGNC:3449
739837
Macaque
chromodomain helicase DNA binding protein 8
708169
Mouse
MGI:1915022
67772
Rat
RGD:620696
65027
Dog
chromodomain helicase DNA binding protein 8
VGNC:39206
475401
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 8
Macaque
chromodomain helicase DNA binding protein 8
Mouse
Rat
Dog
chromodomain helicase DNA binding protein 8
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HCK8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (232)
1 – 10 of 232
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999999991
p_ni:  9e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
HSPB2
Tbio
Novelty:  0.00103909
p_int:  0.999982355
p_ni:  0.000017645
Data Source:  BioPlex
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999960912
p_ni:  0.000039088
Score:  0.313
Data Source:  BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999950698
p_ni:  0.000049302
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999949227
p_ni:  0.000050773
Score:  0.165
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999339545
p_ni:  0.000660455
Score:  0.167
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999291891
p_ni:  0.000708109
Score:  0.161
Data Source:  BioPlex,STRINGDB
NFATC2IP
Tbio
Novelty:  0.02974299
p_int:  0.999222598
p_ni:  0.000777402
Score:  0.426
Data Source:  BioPlex,STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.997924397
p_ni:  0.002075603
Data Source:  BioPlex
RFPL4B
Tdark
Novelty:  2.42779597
p_int:  0.992416038
p_ni:  0.007583945
p_wrong:  1.7e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  115.77

PubMed score by year
PubTator Score  46.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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