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Tbio
AGO4
Protein argonaute-4

Protein Summary
Description
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373210
  • ENSP00000362306
  • ENSG00000134698

Symbol
  • EIF2C4
  • KIAA1567
  • EIF2C4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
microRNA
0.86
biological process
0.8
histone modification site profile
0.74
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.7   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.7   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.998539718
p_ni:  1.1e-8
p_wrong:  0.001460272
Score:  0.484
Data Source:  BioPlex,STRINGDB
PITRM1
Tchem
Family:  Enzyme
Novelty:  0.08067518
p_int:  0.992539276
p_ni:  0.000001017
p_wrong:  0.007459708
Data Source:  BioPlex
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
Score:  0.996
Data Source:  STRINGDB
TNRC6C
Tbio
Novelty:  0.09764186
Score:  0.983
Data Source:  Reactome,STRINGDB
TNRC6A
Tbio
Novelty:  0.00505282
Score:  0.981
Data Source:  Reactome,STRINGDB
XPO5
Tbio
Novelty:  0.0040002
Score:  0.971
Data Source:  STRINGDB
TARBP2
Tbio
Novelty:  0.01485994
Score:  0.968
Data Source:  STRINGDB
TNRC6B
Tbio
Novelty:  0.04520863
Score:  0.967
Data Source:  Reactome,STRINGDB
DROSHA
Tbio
Family:  Enzyme
Novelty:  0.00107123
Score:  0.954
Data Source:  STRINGDB
MOV10
Tbio
Family:  Enzyme
Novelty:  0.01963275
Score:  0.948
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
59
1
1
0
1.1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
59
0
1.1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
argonaute 4, RISC catalytic component
VGNC:38
469278
Macaque
argonaute 4, RISC catalytic component
713134
Mouse
MGI:1924100
76850
Zebrafish
ZDB-GENE-030131-5357
100535764
C. elegans
173468
Species
Name
OMA
EggNOG
Inparanoid
Chimp
argonaute 4, RISC catalytic component
Macaque
argonaute 4, RISC catalytic component
Mouse
Zebrafish
C. elegans
Publication Statistics
PubMed Score 235.70
PubMed score by year
PubTator Score 38.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title