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Tbio
ROBO2
Roundabout homolog 2

Protein Summary
Description
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000461745
  • ENSP00000417164
  • ENSG00000185008
  • ENST00000487694
  • ENSP00000417335

Symbol
  • KIAA1568
  • SAX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
gene perturbation
0.86
biological process
0.78
tissue sample
0.75
disease
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.07   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.07   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
95.2
chronotype measurement
2
3
1
1
95.1
smoking status measurement
2
2
2
82.8
snoring measurement
3
2
2
1
79.9
mathematical ability
2
2
2
67.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
95.2
chronotype measurement
1
1
95.1
smoking status measurement
2
82.8
snoring measurement
2
1
79.9
mathematical ability
2
67.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
roundabout guidance receptor 2
VGNC:12173
460517
Macaque
roundabout guidance receptor 2
719197
Mouse
MGI:1890110
268902
Rat
RGD:620167
84409
Dog
roundabout guidance receptor 2
VGNC:45685
487691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
roundabout guidance receptor 2
Macaque
roundabout guidance receptor 2
Mouse
Rat
Dog
roundabout guidance receptor 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HCK4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
ROBO receptors bind AKAP5
Reactome
Regulation of commissural axon pathfinding by SLIT and ROBO
Reactome
Regulation of cortical dendrite branching
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
ROBO receptors bind AKAP5
Regulation of commissural axon pathfinding by SLIT and ROBO
Regulation of cortical dendrite branching
Gene Ontology Terms (30)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (118)
1 – 10 of 118
SLIT3
Tbio
Novelty: 0.00465012
Score: 0.998
Data Source: Reactome,STRINGDB
SLIT2
Tbio
Novelty: 0.00710401
Score: 0.996
Data Source: Reactome,STRINGDB
SLIT1
Tbio
Novelty: 0.01255624
Score: 0.996
Data Source: Reactome,STRINGDB
ROBO1
Tbio
Novelty: 0.00494884
Score: 0.941
Data Source: STRINGDB
NCK2
Tbio
Novelty: 0.02220251
Score: 0.936
Data Source: Reactome,STRINGDB
SRGAP3
Tbio
Family: Enzyme
Novelty: 0.01913784
Score: 0.935
Data Source: STRINGDB
HOXA2
Tbio
Family: TF
Novelty: 0.00843414
Score: 0.933
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.933
Data Source: STRINGDB
SRGAP2
Tbio
Family: Enzyme
Novelty: 0.02951755
Score: 0.933
Data Source: STRINGDB
LHX2
Tbio
Family: TF
Novelty: 0.00915095
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  140.07

PubMed score by year
PubTator Score  42.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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