Tbio TNRC6C Trinucleotide repeat-containing gene 6C protein

Protein Summary

Description

Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Uniprot Accession IDs

• Q9HCJ0
• G3XAB8
• Q86UE5
• Q8N3D8
• Q96MU9

Gene Name

• TNRC6C

Ensembl ID

• ENST00000301624
• ENSP00000301624
• ENSG00000078687
• ENST00000335749
• ENSP00000336783
• ENST00000588061
• ENSP00000468647
• ENST00000588847
• ENSP00000467154

Symbol

• KIAA1582

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
protein domain	0.92
biological process	0.79
transcription factor perturbation	0.68
pathway	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.41   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.41   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0