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Tbio
TNRC6C
Trinucleotide repeat-containing gene 6C protein

Protein Summary
Description
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301624
  • ENSP00000301624
  • ENSG00000078687
  • ENST00000335749
  • ENSP00000336783
  • ENST00000588061
  • ENSP00000468647
  • ENST00000588847
  • ENSP00000467154

Symbol
  • KIAA1582
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
protein domain
0.92
biological process
0.79
transcription factor perturbation
0.68
pathway
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.79   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.79   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
61.2
mathematical ability
1
1
1
57.8
self reported educational attainment
1
1
1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
61.2
mathematical ability
1
57.8
self reported educational attainment
1
57.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trinucleotide repeat containing 6C
VGNC:48949
741899
Macaque
trinucleotide repeat containing 6C
714829
Mouse
MGI:2443265
217351
Rat
RGD:1310027
303774
Dog
trinucleotide repeat containing 6C
VGNC:47700
483340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trinucleotide repeat containing 6C
Macaque
trinucleotide repeat containing 6C
Mouse
Rat
Dog
trinucleotide repeat containing 6C
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HCJ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (181)
1 – 10 of 181
RACK1
Tbio
Novelty: 0.00200617
p_int: 0.997229594
p_ni: 0.002770406
Score: 0.332
Data Source: BioPlex,STRINGDB
NR2E1
Tbio
Family: NR
Novelty: 0.0184868
p_int: 0.97784577
p_ni: 0.02215423
Score: 0.205
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.973937604
p_ni: 0.026062396
Data Source: BioPlex
DEF6
Tbio
Novelty: 0.0378487
p_int: 0.949805328
p_ni: 0.050194672
Score: 0.188
Data Source: BioPlex,STRINGDB
AGO2
Tbio
Novelty: 0.00057003
Score: 0.994
Data Source: Reactome,STRINGDB
AGO1
Tbio
Novelty: 0.00157424
Score: 0.993
Data Source: Reactome,STRINGDB
PABPC1
Tbio
Novelty: 0.00197523
Score: 0.993
Data Source: STRINGDB
AGO3
Tbio
Novelty: 0.01664154
Score: 0.989
Data Source: Reactome,STRINGDB
AGO4
Tbio
Novelty: 0.00468833
Score: 0.983
Data Source: Reactome,STRINGDB
MOV10
Tbio
Family: Enzyme
Novelty: 0.01963275
Score: 0.959
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  7.79

PubMed score by year
PubTator Score  5.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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