TNRC6C
Trinucleotide repeat-containing gene 6C protein
Protein Summary
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
- ENST00000301624
- ENSP00000301624
- ENSG00000078687
- ENST00000335749
- ENSP00000336783
- ENST00000588061
- ENSP00000468647
- ENST00000588847
- ENSP00000467154
- KIAA1582
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.95 | ||
protein domain | 0.92 | ||
biological process | 0.79 | ||
transcription factor perturbation | 0.68 | ||
pathway | 0.65 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.79 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 51 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.79 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 51 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 61.2 | |||||
mathematical ability | 1 | 1 | 1 | 57.8 | |||||
self reported educational attainment | 1 | 1 | 1 | 57.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 61.2 | |||||
mathematical ability | 1 | 57.8 | |||||
self reported educational attainment | 1 | 57.1 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | trinucleotide repeat containing 6C | VGNC:48949 | 741899 | |||||
Macaque | trinucleotide repeat containing 6C | 714829 | ||||||
Mouse | MGI:2443265 | 217351 | ||||||
Rat | RGD:1310027 | 303774 | ||||||
Dog | trinucleotide repeat containing 6C | VGNC:47700 | 483340 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | trinucleotide repeat containing 6C | |||||
Macaque | trinucleotide repeat containing 6C | |||||
Mouse | ||||||
Rat | ||||||
Dog | trinucleotide repeat containing 6C | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (35)
Reactome (34)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 34
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Gene Ontology Terms (14)
Functions (1)
Components (4)
Processes (9)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (181)
1 – 10 of 181
RACK1
Novelty: 0.00200617
p_int: 0.997229594
p_ni: 0.002770406
Score: 0.332
Data Source: BioPlex,STRINGDB
NR2E1
Family: NR
Novelty: 0.0184868
p_int: 0.97784577
p_ni: 0.02215423
Score: 0.205
Data Source: BioPlex,STRINGDB
AURKA
Family: Kinase
Novelty: 0.0010868
p_int: 0.973937604
p_ni: 0.026062396
Data Source: BioPlex
DEF6
Novelty: 0.0378487
p_int: 0.949805328
p_ni: 0.050194672
Score: 0.188
Data Source: BioPlex,STRINGDB
AGO2
Novelty: 0.00057003
Score: 0.994
Data Source: Reactome,STRINGDB
AGO1
Novelty: 0.00157424
Score: 0.993
Data Source: Reactome,STRINGDB
PABPC1
Novelty: 0.00197523
Score: 0.993
Data Source: STRINGDB
AGO3
Novelty: 0.01664154
Score: 0.989
Data Source: Reactome,STRINGDB
AGO4
Novelty: 0.00468833
Score: 0.983
Data Source: Reactome,STRINGDB
MOV10
Family: Enzyme
Novelty: 0.01963275
Score: 0.959
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 7.79
PubMed score by year
PubTator Score 5.69
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword