Tbio MSL2 E3 ubiquitin-protein ligase MSL2

Protein Summary

Description

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Uniprot Accession IDs

• Q9HCI7
• B4DYL4
• G5E9I1
• Q0D2P1
• Q8NDB4
• Q9NVS4

Gene Name

• MSL2

Ensembl ID

• ENST00000309993
• ENSP00000311827
• ENSG00000174579
• ENST00000434835
• ENSP00000387948

Symbol

• KIAA1585
• MSL2L1
• RNF184
• MSL-2
• MSL2L1
• RNF184

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
transcription factor binding site profile	0.74
cellular component	0.69
kinase perturbation	0.66
microRNA	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.58   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.58   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0