Tdark NCKAP5L Nck-associated protein 5-like

Protein Summary

Description

Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).

Uniprot Accession IDs

• Q9HCH0
• Q2TB26
• Q71RH1
• Q8N4W1
• Q96HX2
• NCKAP5-like

Gene Name

• NCKAP5L

Ensembl ID

• ENST00000335999
• ENSP00000337998
• ENSG00000167566

Symbol

• CEP169
• KIAA1602
• Cep169
• FP1193
• KIAA1602

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.67
cellular component	0.63
histone modification site profile	0.62
cell type or tissue	0.6
tissue sample	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.47   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 15   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.47   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0