Tbio CWC22 Pre-mRNA-splicing factor CWC22 homolog

Protein Summary

Description

Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.

Uniprot Accession IDs

• Q9HCG8
• Q05DC2
• Q4G135
• Q52LF0
• Q6PEX2
• Q7Z6I0
• Q9H5L3
• Q9H6Q6

Gene Name

• CWC22

Ensembl ID

• ENST00000410053
• ENSP00000387006
• ENSG00000163510

Symbol

• KIAA1604
• NCM
• NCM
• fSAPb
• EIF4GL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
tissue sample	0.64
cell type or tissue	0.61
ligand (protein) perturbation	0.59
hub protein	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Pre-mrna-splicing Factor Cwc22 Homolog

DTO Classes

Protein / Enzyme / Nuclease / Pre-mrna-splicing Factor Cwc22 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.27   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.27   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0