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Tchem
TRPM3
Transient receptor potential cation channel subfamily M member 3

Protein Summary
Description
Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
virus perturbation
0.88
disease perturbation
0.83
transcription factor
0.78
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.88   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.88   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (51)
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.988607984
p_ni:  0.000192972
p_wrong:  0.011199044
Data Source:  BioPlex
OSM
Tbio
Novelty:  0.00227405
p_int:  0.982380746
p_ni:  0.000813087
p_wrong:  0.016806166
Score:  0.534
Data Source:  BioPlex,STRINGDB
PHC1
Tbio
Novelty:  0.01530622
p_int:  0.946566436
p_ni:  0.000811045
p_wrong:  0.052622519
Score:  0.189
Data Source:  BioPlex,STRINGDB
NHLH2
Tbio
Family:  TF
Novelty:  0.04744703
p_int:  0.932544125
p_ni:  0.01263427
p_wrong:  0.054821606
Data Source:  BioPlex
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.925111792
p_ni:  0.008146794
p_wrong:  0.066741414
Score:  0.183
Data Source:  BioPlex,STRINGDB
CXCL14
Tbio
Novelty:  0.00606628
p_int:  0.921595851
p_ni:  0.011313884
p_wrong:  0.067090265
Data Source:  BioPlex
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.831364668
p_ni:  0.000622869
p_wrong:  0.168012462
Score:  0.175
Data Source:  BioPlex,STRINGDB
AKAP17A
Tbio
Family:  Enzyme
Novelty:  0.02860381
p_int:  0.78922619
p_ni:  0.010045286
p_wrong:  0.200728524
Score:  0.204
Data Source:  BioPlex,STRINGDB
TRPA1
Tclin
Family:  IC
Novelty:  0.00093648
Score:  0.777
Data Source:  STRINGDB
TRPV2
Tchem
Family:  IC
Novelty:  0.00472952
Score:  0.761
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
92.8
body mass index
2
2
2
64.2
self reported educational attainment
1
2
2
58.9
body height
1
1
1
50.6
daytime rest measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.8
body mass index
2
64.2
self reported educational attainment
2
58.9
body height
1
50.6
daytime rest measurement
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 3
VGNC:13985
464521
Macaque
transient receptor potential cation channel subfamily M member 3
702898
Mouse
MGI:2443101
226025
Rat
RGD:1304888
309407
Dog
transient receptor potential cation channel subfamily M member 3
VGNC:47874
476326
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 3
Macaque
transient receptor potential cation channel subfamily M member 3
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 3
Publication Statistics
PubMed Score 182.88
PubMed score by year
PubTator Score 66.76
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title