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Tbio
ANO8
Anoctamin-8

Protein Summary
Description
Does not exhibit calcium-activated chloride channel (CaCC) activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000159087
  • ENSP00000159087
  • ENSG00000074855

Symbol
  • KIAA1623
  • TMEM16H
  • TMEM16H
  • KIAA1623
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
tissue sample
0.64
molecular function
0.63
transcription factor binding site profile
0.6
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
KNG1
Tbio
Novelty:  0.00007684
Score:  0.908
Data Source:  STRINGDB
TMEM132A
Tdark
Novelty:  0.26489093
Score:  0.905
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.904
Data Source:  STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.904
Data Source:  STRINGDB
LAMB2
Tbio
Novelty:  0.07966931
Score:  0.904
Data Source:  STRINGDB
MEN1
Tchem
Novelty:  0.00059287
Score:  0.903
Data Source:  STRINGDB
PNPLA2
Tchem
Family:  Enzyme
Novelty:  0.00149181
Score:  0.903
Data Source:  STRINGDB
GAS6
Tbio
Novelty:  0.00297606
Score:  0.903
Data Source:  STRINGDB
IGFBP5
Tchem
Novelty:  0.0025185
Score:  0.902
Data Source:  STRINGDB
VGF
Tbio
Novelty:  0.00521876
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Ion channel transport
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.2
93.9
testosterone measurement
4
2
4
92.7
2
3
0
1.2
92.6
mitochondrial DNA measurement
2
3
3
90
sex hormone-binding globulin measurement
6
1
6
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
93.9
testosterone measurement
4
92.7
0
1.2
92.6
mitochondrial DNA measurement
3
90
sex hormone-binding globulin measurement
6
88.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anoctamin 8
VGNC:2092
104004543
Mouse
MGI:2687327
382014
Rat
RGD:1563946
306340
Dog
anoctamin 8
VGNC:37930
484839
Horse
anoctamin 8 [Source:HGNC Symbol;Acc:HGNC:29329]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anoctamin 8
Mouse
Rat
Dog
anoctamin 8
Horse
anoctamin 8 [Source:HGNC Symbol;Acc:HGNC:29329]
Publication Statistics
PubMed Score 3.04
PubMed score by year
PubTator Score 2.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title