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Tchem
SMURF1
E3 ubiquitin-protein ligase SMURF1

Protein Summary
Description
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003). This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361125
  • ENSP00000354621
  • ENSG00000198742
  • ENST00000361368
  • ENSP00000355326
  • ENST00000638461
  • ENSP00000491036
  • ENSG00000284126
  • ENST00000638647
  • ENSP00000492201

Symbol
  • KIAA1625
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
hub protein
0.94
cell type or tissue
0.79
transcription factor binding site profile
0.67
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.67   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.67   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 78
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (78)
1 – 10 of 78
CHEMBL4584197
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CHEMBL4475920
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CHEMBL4559578
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CHEMBL4468431
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CHEMBL4473531
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CHEMBL3903549
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CHEMBL3949800
Rendered image for CHEMBL3949800
CHEMBL3948610
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CHEMBL3918128
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CHEMBL3908757
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GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3
3
90.4
mean reticulocyte volume
1
3
3
90.4
mean corpuscular volume
1
3
3
87.5
mean corpuscular volume
1
3
3
87.5
eosinophil count
2
1
2
56.4
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
3
90.4
mean reticulocyte volume
3
90.4
mean corpuscular volume
3
87.5
mean corpuscular volume
3
87.5
eosinophil count
2
56.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMAD specific E3 ubiquitin protein ligase 1
VGNC:4509
472670
Macaque
SMAD specific E3 ubiquitin protein ligase 1
718616
Mouse
MGI:1923038
75788
Rat
RGD:1594738
690516
Dog
SMAD specific E3 ubiquitin protein ligase 1
VGNC:46580
608821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMAD specific E3 ubiquitin protein ligase 1
Macaque
SMAD specific E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
SMAD specific E3 ubiquitin protein ligase 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HCE7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (40)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (37)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Protein-Protein Interactions (404)
1 – 10 of 404
SMURF2
Tchem
Family:  Enzyme
Novelty:  0.00920984
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999485361
p_ni:  0.000514633
p_wrong:  6e-9
Score:  0.578
Data Source:  BioPlex,STRINGDB
SPART
Tbio
Novelty:  0.01524727
p_int:  0.998923014
p_ni:  0.001076986
p_wrong:  1e-9
Score:  0.372
Data Source:  BioPlex,STRINGDB
EPN3
Tbio
Novelty:  0.12685855
p_int:  0.998378517
p_ni:  0.001621482
p_wrong:  1e-9
Score:  0.324
Data Source:  BioPlex,STRINGDB
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
Score:  0.999
Data Source:  Reactome,STRINGDB
SMAD6
Tbio
Family:  TF
Novelty:  0.00488425
Score:  0.994
Data Source:  Reactome,STRINGDB
SMAD5
Tbio
Family:  TF
Novelty:  0.00405952
Score:  0.987
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.986
Data Source:  STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.985
Data Source:  STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.984
Data Source:  STRINGDB
Publication Statistics
PubMed Score  145.67

PubMed score by year
PubTator Score  79.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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