Tchem SMURF1 E3 ubiquitin-protein ligase SMURF1

Protein Summary

Description

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003). This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q9HCE7
• A4D279
• B7ZMB6
• B9EGV3
• O75853
• Q547Q3
• Q9UJT8
• hSMURF1

Gene Name

• SMURF1

Ensembl ID

• ENST00000361125
• ENSP00000354621
• ENSG00000198742
• ENST00000361368
• ENSP00000355326
• ENST00000638461
• ENSP00000491036
• ENSG00000284126
• ENST00000638647
• ENSP00000492201

Symbol

• KIAA1625

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
hub protein	0.94
cell type or tissue	0.79
transcription factor binding site profile	0.67
cellular component	0.65

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Smurf1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Smurf1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.99   (req: < 5)

Gene RIFs: 99   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.99   (req: >= 5)

Gene RIFs: 99   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 78

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0