ARHGEF10L
Rho guanine nucleotide exchange factor 10-like protein
Protein Summary
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]
- ENST00000361221
- ENSP00000355060
- ENSG00000074964
- ENST00000375415
- ENSP00000364564
- GRINCHGEF
- KIAA1626
- GrinchGEF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.94 | ||
interacting protein | 0.89 | ||
transcription factor | 0.8 | ||
cell type or tissue | 0.69 | ||
histone modification site profile | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.29 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 35 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.29 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 35 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0