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Tbio
ARHGEF10L
Rho guanine nucleotide exchange factor 10-like protein

Protein Classes
Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361221
  • ENSP00000355060
  • ENSG00000074964
  • ENST00000375415
  • ENSP00000364564

Symbol
  • GRINCHGEF
  • KIAA1626
  • GrinchGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
interacting protein
0.89
transcription factor
0.8
cell type or tissue
0.69
histone modification site profile
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 10 like
VGNC:6717
456533
Macaque
Rho guanine nucleotide exchange factor 10 like
701164
Mouse
MGI:1920004
72754
Dog
Rho guanine nucleotide exchange factor 10 like
VGNC:38073
487411
Horse
Rho guanine nucleotide exchange factor 10 like
VGNC:15482
100052916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 10 like
Macaque
Rho guanine nucleotide exchange factor 10 like
Mouse
Dog
Rho guanine nucleotide exchange factor 10 like
Horse
Rho guanine nucleotide exchange factor 10 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCE6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Protein-Protein Interactions (47)
1 – 10 of 47
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.94
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.939
Data Source: STRINGDB
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
Score: 0.92
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.919
Data Source: STRINGDB
RHOF
Tbio
Family: Enzyme
Novelty: 0.01795771
Score: 0.916
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.00412327
Score: 0.915
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.915
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.91
Data Source: STRINGDB
RHOBTB2
Tbio
Novelty: 0.00734789
Score: 0.91
Data Source: STRINGDB
RHOV
Tbio
Family: Enzyme
Novelty: 0.02138482
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.97

PubMed score by year
PubTator Score  0.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer