Tbio MOV10 Helicase MOV-10

Protein Summary

Description

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Uniprot Accession IDs

• Q9HCE1
• Q5JR03
• Q8TEF0
• Q9BSY3
• Q9BUJ9

Gene Name

• MOV10

Ensembl ID

• ENST00000357443
• ENSP00000350028
• ENSG00000155363
• ENST00000369645
• ENSP00000358659
• ENST00000413052
• ENSP00000399797

Symbol

• KIAA1631
• gb110
• fSAP113

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
virus perturbation	0.97
molecular function	0.95
transcription factor binding site profile	0.88
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Helicase Mov-10

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Helicase Mov-10

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Helicase Mov-10

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Helicase Mov-10

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Helicase Mov-10

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Helicase Mov-10

Protein / Hydrolase / Helicase Mov-10

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Putative Helicase Mov-10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.43   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.43   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0