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Tbio
MOV10
Helicase MOV-10

Protein Summary
Description
5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskele ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357443
  • ENSP00000350028
  • ENSG00000155363
  • ENST00000369645
  • ENSP00000358659
  • ENST00000413052
  • ENSP00000399797

Symbol
  • KIAA1631
  • gb110
  • fSAP113
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
virus perturbation
0.97
molecular function
0.95
transcription factor binding site profile
0.88
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.06   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.06   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (256)
1 – 10 of 256
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.993705944
p_ni:  0.006294056
Score:  0.218
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.981682258
p_ni:  0.018317742
Data Source:  BioPlex
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.955835092
p_ni:  0.044164908
Score:  0.178
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.955769587
p_ni:  0.044230413
Data Source:  BioPlex
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.950275199
p_ni:  0.049724801
Score:  0.312
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.948075804
p_ni:  0.051924196
Score:  0.342
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.947748644
p_ni:  0.052251356
Data Source:  BioPlex
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.941410732
p_ni:  0.058589268
Score:  0.23
Data Source:  BioPlex,STRINGDB
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.936486124
p_ni:  0.06351387
p_wrong:  7e-9
Data Source:  BioPlex
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.933881279
p_ni:  0.066118721
Data Source:  BioPlex
Pathways (32)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5
6
8.1
96.9
creatinine measurement
2
2
2
92.5
platelet count
2
2
2
91.9
testosterone measurement
2
2
2
88.5
diastolic blood pressure
3
3
6
86.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
8.1
96.9
creatinine measurement
2
92.5
platelet count
2
91.9
testosterone measurement
2
88.5
diastolic blood pressure
6
86.9
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Mov10 RISC complex RNA helicase
VGNC:1326
457099
Mouse
MGI:97054
17454
Rat
RGD:1598327
310756
Dog
Mov10 RISC complex RNA helicase
VGNC:43327
483219
Horse
Mov10 RISC complex RNA helicase
VGNC:20275
100059089
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Mov10 RISC complex RNA helicase
Mouse
Rat
Dog
Mov10 RISC complex RNA helicase
Horse
Mov10 RISC complex RNA helicase
Publication Statistics
PubMed Score 57.06
PubMed score by year
PubTator Score 28.40
PubTator score by year