Tbio EPG5 Ectopic P granules protein 5 homolog

Protein Summary

Description

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q9HCE0
• A2BDF3
• Q9H8C8

Gene Name

• EPG5

Ensembl ID

• ENST00000282041
• ENSP00000282041
• ENSG00000152223
• ENST00000649336
• ENSP00000497269

Symbol

• KIAA1632
• HEEW1
• VICIS
• KIAA1632

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
microRNA	0.62
transcription factor perturbation	0.61
cell line	0.54
kinase perturbation	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.75   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.75   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0