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Tdark
TANC2
Protein TANC2

Related Tools
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ARCHS4
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
72.9
insomnia measurement
1
1
0
1.1
41.2
chronotype measurement
1
1
1
40.6
optic disc size measurement
1
1
1
35.9
intelligence
1
1
1
19.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
72.9
insomnia measurement
0
1.1
41.2
chronotype measurement
1
40.6
optic disc size measurement
1
35.9
intelligence
1
19.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
VGNC:9674
454784
Mouse
MGI:2444121
77097
Rat
RGD:1309285
303599
Dog
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
VGNC:47099
480483
Horse
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
VGNC:23865
100054415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Mouse
Rat
Dog
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Horse
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (33)
1 – 10 of 33
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.999999956
p_ni: 2.9e-8
p_wrong: 1.5e-8
Score: 0.607
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999999941
p_ni: 4.2e-8
p_wrong: 1.7e-8
Score: 0.608
Data Source: BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.999999813
p_ni: 1.86e-7
Data Source: BioPlex
ZYX
Tbio
Novelty: 0.00375452
p_int: 0.99999284
p_ni: 0.00000716
Score: 0.369
Data Source: BioPlex,STRINGDB
PAK5
Tchem
Family: Kinase
Novelty: 0.02138632
p_int: 0.999971845
p_ni: 0.000028155
Score: 0.284
Data Source: BioPlex,STRINGDB
FJX1
Tbio
Novelty: 0.07957088
Score: 0.707
Data Source: STRINGDB
ZFAND5
Tbio
Novelty: 0.09728886
Score: 0.668
Data Source: STRINGDB
CHKA
Tchem
Family: Kinase
Novelty: 0.00237839
Score: 0.653
Data Source: STRINGDB
DLG5
Tbio
Novelty: 0.01630244
Score: 0.634
Data Source: STRINGDB
TRMT13
Tdark
Novelty: 3.91234304
Score: 0.597
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.65

PubMed score by year
PubTator Score  7.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer