Tbio NCOA5 Nuclear receptor coactivator 5

Protein Summary

Description

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9HCD5
• B2RTV9
• E1P5R0
• Q6HA99
• Q9H1F2
• Q9H2T2
• Q9H4Y9
• NCoA-5

Gene Name

• NCOA5

Ensembl ID

• ENST00000290231
• ENSP00000290231
• ENSG00000124160

Symbol

• KIAA1637
• CIA
• bA465L10.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
ligand (protein) perturbation	0.83
virus perturbation	0.83
interacting protein	0.63
cell type or tissue	0.62

Protein Classes

PANTHER Classes

Protein / Receptor / Nuclear Receptor Coactivator 5

DTO Classes

Protein / Receptor / Nuclear Receptor Coactivator 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.88   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.88   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0