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Tbio
NCOA5
Nuclear receptor coactivator 5

Protein Classes
Protein Summary
Description
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290231
  • ENSP00000290231
  • ENSG00000124160

Symbol
  • KIAA1637
  • CIA
  • bA465L10.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
ligand (protein) perturbation
0.83
virus perturbation
0.83
interacting protein
0.63
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.04   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.04   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (85)
1 – 10 of 85
NUDT12
Tbio
Family: Enzyme
Novelty: 0.40327445
p_int: 0.999989816
p_ni: 0.000010184
Score: 0.219
Data Source: BioPlex,STRINGDB
HTATIP2
Tbio
Family: Enzyme
Novelty: 0.01999704
p_int: 0.999820956
p_ni: 0.000179044
Score: 0.561
Data Source: BioPlex,STRINGDB
RBMX
Tbio
Novelty: 0.02400029
p_int: 0.994306071
p_ni: 0.005693738
p_wrong: 1.92e-7
Score: 0.381
Data Source: BioPlex,STRINGDB
LARP4B
Tbio
Novelty: 0.153294
p_int: 0.994037623
p_ni: 0.005962219
p_wrong: 1.59e-7
Data Source: BioPlex
GALC
Tbio
Family: Enzyme
Novelty: 0.00289873
p_int: 0.99225957
p_ni: 0.00774043
Score: 0.278
Data Source: BioPlex,STRINGDB
EIF4B
Tbio
Novelty: 0.00890725
p_int: 0.982891694
p_ni: 0.017078213
p_wrong: 0.000030093
Score: 0.181
Data Source: BioPlex,STRINGDB
CLK2
Tchem
Family: Kinase
Novelty: 0.36216831
p_int: 0.981163733
p_ni: 0.018836267
Score: 0.155
Data Source: BioPlex,STRINGDB
LRRC4C
Tbio
Novelty: 0.00535393
p_int: 0.969683417
p_ni: 0.030316583
Score: 0.181
Data Source: BioPlex,STRINGDB
RPS16
Tbio
Novelty: 0.00413292
p_int: 0.935541151
p_ni: 0.059035009
p_wrong: 0.00542384
Data Source: BioPlex
SFPQ
Tbio
Novelty: 0.01546419
p_int: 0.857398181
p_ni: 0.142574842
p_wrong: 0.000026977
Score: 0.27
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.04

PubMed score by year
PubTator Score  220.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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