Tbio ZFYVE28 Lateral signaling target protein 2 homolog

Protein Summary

Description

Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.

Uniprot Accession IDs

• Q9HCC9
• B2RP83
• B3KX50
• B7Z1Q7
• B7Z2G9
• B7Z2M2
• B7ZB19
• E9PB54
• E9PB64
• E9PG77
• Q7Z6J3
• hLst2

Gene Name

• ZFYVE28

Ensembl ID

• ENST00000290974
• ENSP00000290974
• ENSG00000159733
• ENST00000503000
• ENSP00000423694
• ENST00000509171
• ENSP00000422638
• ENST00000511071
• ENSP00000425706
• ENST00000515169
• ENSP00000425766
• ENST00000515312
• ENSP00000426299

Symbol

• KIAA1643
• LST2
• LST2
• LYST2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.79
transcription factor	0.77
virus perturbation	0.68
cell line	0.65
cellular component	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0