Tbio SPON1 Spondin-1

Protein Summary

Description

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.

Uniprot Accession IDs

• Q9HCB6
• A8K6W5
• O94862
• Q8NCD7
• Q8WUR5

Gene Name

• SPON1

Ensembl ID

• ENST00000576479
• ENSP00000460236
• ENSG00000262655

Symbol

• KIAA0762
• VSGP
• f-spondin
• VSGP/F-spondin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.96
kinase perturbation	0.71
small molecule perturbation	0.71
phenotype	0.7
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Spondin-1

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Spondin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.08   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.08   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0