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Tbio
SPON1
Spondin-1

Protein Summary
Description
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000576479
  • ENSP00000460236
  • ENSG00000262655

Symbol
  • KIAA0762
  • VSGP
  • f-spondin
  • VSGP/F-spondin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
kinase perturbation
0.71
small molecule perturbation
0.71
phenotype
0.7
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.66   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.66   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
DPY19L3
Tbio
Family:  Enzyme
Novelty:  0.35244121
p_int:  0.999999443
p_ni:  5.57e-7
Data Source:  BioPlex
C5orf22
Tdark
Novelty:  1.29325352
p_int:  0.999989044
p_ni:  0.000010757
p_wrong:  2e-7
Data Source:  BioPlex
SULF2
Tbio
Family:  Enzyme
Novelty:  0.01536228
p_int:  0.999450809
p_ni:  0.00054919
p_wrong:  1e-9
Data Source:  BioPlex
LY86
Tbio
Novelty:  0.00314575
p_int:  0.99760595
p_ni:  0.000222411
p_wrong:  0.002171638
Data Source:  BioPlex
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.99603597
p_ni:  0.00396403
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.994446041
p_ni:  0.005526936
p_wrong:  0.000027023
Data Source:  BioPlex
WDR26
Tbio
Novelty:  0.04140166
p_int:  0.993255618
p_ni:  0.006744383
Data Source:  BioPlex
MAEA
Tbio
Novelty:  0.00833813
p_int:  0.990469242
p_ni:  0.009530758
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.987012069
p_ni:  0.012987931
Data Source:  BioPlex
GID8
Tbio
Novelty:  0.21243963
p_int:  0.981752038
p_ni:  0.018247962
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
6
23
26
99.6
spondin-1 measurement
1
2
2
95.4
BMI-adjusted hip circumference
2
8
8
90
blood protein measurement
1
1
1
81.1
hip circumference
1
3
3
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
26
99.6
spondin-1 measurement
2
95.4
BMI-adjusted hip circumference
8
90
blood protein measurement
1
81.1
hip circumference
3
80.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spondin 1
699833
Mouse
MGI:2385287
233744
Rat
RGD:619918
64456
Dog
spondin 1
VGNC:46752
476864
Horse
spondin 1 [Source:HGNC Symbol;Acc:HGNC:11252]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spondin 1
Mouse
Rat
Dog
spondin 1
Horse
spondin 1 [Source:HGNC Symbol;Acc:HGNC:11252]
Publication Statistics
PubMed Score 90.66
PubMed score by year
PubTator Score 32.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title