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Tchem
NEK6
Serine/threonine-protein kinase Nek6

Protein Summary
Description
Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320246
  • ENSP00000319734
  • ENSG00000119408
  • ENST00000373600
  • ENSP00000362702
  • ENST00000373603
  • ENSP00000362705
  • ENST00000394199
  • ENSP00000377749
  • ENST00000539416
  • ENSP00000439651
  • ENST00000540326
  • ENSP00000441469
  • ENST00000545174
  • ENSP00000442636
  • ENST00000546191
  • ENSP00000441426

Symbol
  • SID6-1512
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
molecular function
0.99
kinase perturbation
0.98
transcription factor
0.88


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.5   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.5   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
tamatinib
Rendered image for tamatinib
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
85.6
monocyte count
2
2
2
82.5
platelet count
2
2
2
76
platelet crit
2
2
2
74.5
hair color
1
2
0
1.1
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
85.6
monocyte count
2
82.5
platelet count
2
76
platelet crit
2
74.5
hair color
0
1.1
67.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 6
VGNC:13922
737739
Macaque
NIMA related kinase 6
100427402
Mouse
MGI:1891638
59126
Rat
RGD:727779
360161
Dog
NIMA related kinase 6
VGNC:43733
609003
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 6
Macaque
NIMA related kinase 6
Mouse
Rat
Dog
NIMA related kinase 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HC98-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (R-HSA-2980767)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NIMA Kinases NEK9, NEK6, NEK7
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Activation of NIMA Kinases NEK9, NEK6, NEK7
Cell Cycle
Cell Cycle, Mitotic
M Phase
Mitotic Prophase
Gene Ontology Terms (30)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (88)
1 – 10 of 88
NEK7
Tchem
Family:  Kinase
Novelty:  0.02675561
p_int:  0.999999888
p_ni:  3.1e-8
p_wrong:  8.1e-8
Score:  0.982
Data Source:  BioPlex,STRINGDB
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.999998669
p_ni:  0.000001297
p_wrong:  3.4e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.999887756
p_ni:  0.000111591
p_wrong:  6.52e-7
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.999792206
p_ni:  0.000168804
p_wrong:  0.00003899
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.999295661
p_ni:  0.000703556
p_wrong:  7.83e-7
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.991416196
p_ni:  0.002107451
p_wrong:  0.006476353
Data Source:  BioPlex
NEK9
Tchem
Family:  Kinase
Novelty:  0.02386353
p_int:  0.982898868
p_ni:  0.017101132
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
NUP205
Tbio
Novelty:  0.06778513
Score:  0.918
Data Source:  STRINGDB
NUP35
Tbio
Novelty:  0.0355102
Score:  0.915
Data Source:  STRINGDB
NUP93
Tbio
Novelty:  0.0248311
Score:  0.913
Data Source:  STRINGDB
Publication Statistics
PubMed Score  46.50

PubMed score by year
PubTator Score  34.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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