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Tchem
GPR35
G-protein coupled receptor 35

Protein Summary
Description
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319838
  • ENSP00000322731
  • ENSG00000178623
  • ENST00000403859
  • ENSP00000385140
  • ENST00000407714
  • ENSP00000384263
  • ENST00000430267
  • ENSP00000411788
  • ENST00000438013
  • ENSP00000415890
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.79
tissue sample
0.68
tissue
0.59
gene perturbation
0.56
transcription factor
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.02   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.02   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 71
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2