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Tchem
GPR35
G-protein coupled receptor 35

Protein Summary
Description
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319838
  • ENSP00000322731
  • ENSG00000178623
  • ENST00000403859
  • ENSP00000385140
  • ENST00000407714
  • ENSP00000384263
  • ENST00000430267
  • ENSP00000411788
  • ENST00000438013
  • ENSP00000415890
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.79
tissue sample
0.68
tissue
0.59
gene perturbation
0.56
transcription factor
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.53   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.53   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
dicoumarol
chemical structure image
lodoxamide
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
95.7
monocyte count
2
1
2
81.3
1
1
0
1.4
66.8
1
1
0
1.1
66.8
1
1
0
1.4
62.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
95.7
monocyte count
2
81.3
0
1.4
66.8
0
1.1
66.8
0
1.4
62.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 35
VGNC:1951
460070
Macaque
G protein-coupled receptor 35
699073
Mouse
MGI:1929509
64095
Rat
RGD:1309404
367315
Dog
G-protein coupled receptor 35-like
100855802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 35
Macaque
G protein-coupled receptor 35
Mouse
Rat
Dog
G-protein coupled receptor 35-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HC97-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (50)
1 – 10 of 50
POTEE
Tbio
Novelty: 0.29349205
p_int: 0.999996112
p_ni: 0.000003827
p_wrong: 6.1e-8
Score: 0.295
Data Source: BioPlex,STRINGDB
ATP5IF1
Tbio
Family: Enzyme
Novelty: 0.01272196
p_int: 0.95199191
p_ni: 0.04800809
Score: 0.873
Data Source: BioPlex,STRINGDB
KTI12
Tdark
Novelty: 0.08954294
p_int: 0.949330827
p_ni: 7.1e-8
p_wrong: 0.050669103
Score: 0.689
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.924303749
p_ni: 0.075696251
Data Source: BioPlex
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
p_int: 0.880560427
p_ni: 0.119439573
Score: 0.23
Data Source: BioPlex,STRINGDB
CXCL17
Tbio
Novelty: 0.0333432
Score: 0.734
Data Source: STRINGDB
CAPN10
Tbio
Novelty: 0.00497347
Score: 0.711
Data Source: STRINGDB
GPR84
Tchem
Family: GPCR
Novelty: 0.02360587
Score: 0.651
Data Source: STRINGDB
KMO
Tchem
Family: Enzyme
Novelty: 0.01469543
Score: 0.621
Data Source: STRINGDB
AADAT
Tchem
Family: Enzyme
Novelty: 0.00678753
Score: 0.608
Data Source: STRINGDB
Publication Statistics
PubMed Score  101.53

PubMed score by year
PubTator Score  54.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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