Tbio CAPN10 Calpain-10

Protein Summary

Description

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9HC96
• A8MVS7
• Q4ZFV1
• Q8NCD4
• Q96IG4
• Q96JI2
• Q9HC89
• Q9HC90
• Q9HC91
• Q9HC92
• Q9HC93
• Q9HC94
• Q9HC95

Gene Name

• CAPN10

Ensembl ID

• ENST00000270361
• ENSP00000270361
• ENSG00000142330
• ENST00000270364
• ENSP00000270364
• ENST00000352879
• ENSP00000289381
• ENST00000354082
• ENSP00000270362
• ENST00000357048
• ENSP00000349556
• ENST00000391983
• ENSP00000375843
• ENST00000391984
• ENSP00000375844
• ENST00000416591
• ENSP00000400144

Symbol

• KIAA1845
• CANP10
• NIDDM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.89
histone modification site profile	0.85
protein domain	0.85
disease perturbation	0.79
tissue sample	0.73

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Calpain-10

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calpain-10

Protein / Calcium-binding Protein / Annexin / Calpain-10

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Calpain-10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.57   (req: < 5)

Gene RIFs: 127   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.57   (req: >= 5)

Gene RIFs: 127   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0