Pharos : Target Details

Protein Classes

Protein Summary

Description

Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

Gene Name

MUC5B

Ensembl ID

ENST00000529681
ENSP00000436812
ENSG00000117983

Symbol

MUC5
MG1
MUC5
MUC9
MUC-5B

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92

cell line	0.79

cellular component	0.76

biological term	0.72

disease	0.57

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.74 (req: < 5)

View Publications

Gene RIFs: 113 (req: <= 3)

View Gene RIFs

Antibodies: 298 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.74 (req: >= 5)

Gene RIFs: 113 (req: > 3)

Antibodies: 298 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
idiopathic pulmonary fibrosis	EFO_0000768	3	3	0	2.4	96.7

asthma	EFO_0000270	4	3	0	1.1	75.9

adult onset asthma	EFO_1002011	2	2	0	1.1	54.3

interstitial lung disease	EFO_0004244	2	1	0	2.1	38.7

Inhalant adrenergic use measurement	EFO_0009941	1	1	1		6.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
idiopathic pulmonary fibrosis	EFO_0000768	0	2.4	96.7

asthma	EFO_0000270	0	1.1	75.9

adult onset asthma	EFO_1002011	0	1.1	54.3

interstitial lung disease	EFO_0004244	0	2.1	38.7

Inhalant adrenergic use measurement	EFO_0009941	1		6.6

Beta Count

Odds Ratio

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID
Macaque	mucin-5B-like		100429390

Rat	mucin 5B, oligomeric mucus/gel-forming	RGD:1561983	309114

Dog	mucin 5B, oligomeric mucus/gel-forming	VGNC:49928	483656

Species	Name	OMA	EggNOG	Inparanoid
Macaque	mucin-5B-like

Rat	mucin 5B, oligomeric mucus/gel-forming

Dog	mucin 5B, oligomeric mucus/gel-forming

Protein Structure (0 Structures, 23 AlphaFold Models)

Pathways (18)

Reactome (15)

KEGG (2)

WikiPathways (1)

C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481

Reactome	Dectin-2 family	29 targets	R-HSA-5621480

Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632

Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636

Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481

Dectin-2 family	29 targets	R-HSA-5621480

Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632

Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Gene Ontology Terms (7)

Components (5)

Processes (2)

Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
intracellular membrane-bounded organelle	Inferred from Direct Assay (IDA)	HPA

extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

extracellular space	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Golgi lumen	Traceable Author Statement (TAS)	Reactome

plasma membrane	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (112)

1 – 10 of 112

See Interactions on String-DB

ICE2

Tbio

Novelty: 0.03407933

p_int: 0.999999606

p_ni: 3.94e-7

Score: 0.204

Data Source: BioPlex,STRINGDB

FRMD1

Tdark

Novelty: 0.96833141

p_int: 0.99999883

p_ni: 0.00000117

Data Source: BioPlex

PCK2

Tbio

Family: Kinase

Novelty: 0.0035563

p_int: 0.999998673

p_ni: 0.000001327

Score: 0.187

Data Source: BioPlex,STRINGDB

HBM

Tdark

Novelty: 0.02658671

p_int: 0.999997697

p_ni: 0.000002303

Score: 0.175

Data Source: BioPlex,STRINGDB

SNW1

Tbio

Novelty: 0.01423797

p_int: 0.999994209

p_ni: 0.000005791

Data Source: BioPlex

ARHGAP12

Tbio

Family: Enzyme

Novelty: 0.12113722

p_int: 0.999912443

p_ni: 0.00008687

p_wrong: 6.87e-7

Score: 0.325

Data Source: BioPlex,STRINGDB

TIMM50

Tbio

Family: Enzyme

Novelty: 0.0238053

p_int: 0.999881438

p_ni: 0.00011856

p_wrong: 2e-9

Data Source: BioPlex

DDX31

Tbio

Family: Enzyme

Novelty: 2.84646195

p_int: 0.999110724

p_ni: 0.000730317

p_wrong: 0.000158959

Score: 0.187

Data Source: BioPlex,STRINGDB

KIR2DS2

Tdark

p_int: 0.998915497

p_ni: 0.000985841

p_wrong: 0.000098661

Data Source: BioPlex

JAK2

Tclin

Family: Kinase

Novelty: 0.00022894

p_int: 0.977118355

p_ni: 0.022784996

p_wrong: 0.000096649

Score: 0.218

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score 1286.74

PubMed score by year

PubTator Score 489.95

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

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