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Tbio
MUC5B
Mucin-5B

Protein Summary
Description
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell line
0.79
cellular component
0.76
biological term
0.72
disease
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.74   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.74   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
2.4
96.7
4
3
0
1.1
75.9
adult onset asthma
2
2
0
1.1
54.3
2
1
0
2.1
38.7
Inhalant adrenergic use measurement
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.4
96.7
0
1.1
75.9
adult onset asthma
0
1.1
54.3
0
2.1
38.7
Inhalant adrenergic use measurement
1
6.6
Protein Structure (0 Structures, 23 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Protein-Protein Interactions (112)
1 – 10 of 112
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.999999606
p_ni:  3.94e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.99999883
p_ni:  0.00000117
Data Source:  BioPlex
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.999998673
p_ni:  0.000001327
Score:  0.187
Data Source:  BioPlex,STRINGDB
HBM
Tdark
Novelty:  0.02658671
p_int:  0.999997697
p_ni:  0.000002303
Score:  0.175
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.999994209
p_ni:  0.000005791
Data Source:  BioPlex
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.999912443
p_ni:  0.00008687
p_wrong:  6.87e-7
Score:  0.325
Data Source:  BioPlex,STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
p_int:  0.999881438
p_ni:  0.00011856
p_wrong:  2e-9
Data Source:  BioPlex
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999110724
p_ni:  0.000730317
p_wrong:  0.000158959
Score:  0.187
Data Source:  BioPlex,STRINGDB
KIR2DS2
Tdark
p_int:  0.998915497
p_ni:  0.000985841
p_wrong:  0.000098661
Data Source:  BioPlex
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
p_int:  0.977118355
p_ni:  0.022784996
p_wrong:  0.000096649
Score:  0.218
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1286.74

PubMed score by year
PubTator Score  489.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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