Protein Summary
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
- ENST00000529681
- ENSP00000436812
- ENSG00000117983
- MUC5
- MG1
- MUC5
- MUC9
- MUC-5B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
cell line | 0.79 | ||
cellular component | 0.76 | ||
biological term | 0.72 | ||
disease | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1286.74 (req: < 5)
Gene RIFs: 113 (req: <= 3)
Antibodies: 298 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1286.74 (req: >= 5)
Gene RIFs: 113 (req: > 3)
Antibodies: 298 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (112)
ICE2
Novelty: 0.03407933
p_int: 0.999999606
p_ni: 3.94e-7
Score: 0.204
Data Source: BioPlex,STRINGDB
PCK2
Family: Kinase
Novelty: 0.0035563
p_int: 0.999998673
p_ni: 0.000001327
Score: 0.187
Data Source: BioPlex,STRINGDB
HBM
Novelty: 0.02658671
p_int: 0.999997697
p_ni: 0.000002303
Score: 0.175
Data Source: BioPlex,STRINGDB
ARHGAP12
Family: Enzyme
Novelty: 0.12113722
p_int: 0.999912443
p_ni: 0.00008687
p_wrong: 6.87e-7
Score: 0.325
Data Source: BioPlex,STRINGDB
TIMM50
Family: Enzyme
Novelty: 0.0238053
p_int: 0.999881438
p_ni: 0.00011856
p_wrong: 2e-9
Data Source: BioPlex
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999110724
p_ni: 0.000730317
p_wrong: 0.000158959
Score: 0.187
Data Source: BioPlex,STRINGDB
JAK2
Family: Kinase
Novelty: 0.00022894
p_int: 0.977118355
p_ni: 0.022784996
p_wrong: 0.000096649
Score: 0.218
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (15)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Dectin-2 family | ||||
Reactome | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Reactome | Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Reactome | Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Dectin-2 family | ||||
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 3 | 0 | 2.4 | 96.7 | |||||
4 | 3 | 0 | 1.1 | 75.9 | |||||
adult onset asthma | 2 | 2 | 0 | 1.1 | 54.3 | ||||
2 | 1 | 0 | 2.1 | 38.7 | |||||
Inhalant adrenergic use measurement | 1 | 1 | 1 | 6.6 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 2.4 | 96.7 | |||||
0 | 1.1 | 75.9 | |||||
adult onset asthma | 0 | 1.1 | 54.3 | ||||
0 | 2.1 | 38.7 | |||||
Inhalant adrenergic use measurement | 1 | 6.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | mucin-5B-like | 100429390 | ||||||
Rat | RGD:1561983 | 309114 | ||||||
Dog | mucin 5B, oligomeric mucus/gel-forming | VGNC:49928 | 483656 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | mucin-5B-like | |||||
Rat | ||||||
Dog | mucin 5B, oligomeric mucus/gel-forming | |||||
Publication Statistics
PubMed Score 1286.74
PubMed score by year
PubTator Score 489.95
PubTator score by year
Related Publications
Text Mined References (149)
GeneRif Annotations (113)
Items per page:
0 of 0
PMID | Year | Title |
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