Tbio MUC5B Mucin-5B

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Mucin-5b

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Mucin-5b

Protein Summary

Description

Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9HC84
• O00447
• O00573
• O14985
• O15494
• O95291
• O95451
• Q14881
• Q7M4S5
• Q99552
• Q9UE28
• MUC-5B

Gene Name

• MUC5B

Ensembl ID

• ENST00000529681
• ENSP00000436812
• ENSG00000117983

Symbol

• MUC5
• MG1
• MUC5
• MUC9
• MUC-5B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
cell line	0.79
cellular component	0.76
biological term	0.72
disease	0.57

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1063.5   (req: < 5)

Gene RIFs: 113   (req: <= 3)

Antibodies: 298   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1063.5   (req: >= 5)

Gene RIFs: 113   (req: > 3)

Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (18)

Reactome (15)

KEGG (2)

WikiPathways (1)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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Items per page:

5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)