Tbio CENPJ Centromere protein J

Protein Summary

Description

Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q9HC77
• Q2KHM6
• Q5JPD5
• Q5T6R5
• Q96KS5
• Q9C067
• CENP-J

Gene Name

• CENPJ

Ensembl ID

• ENST00000381884
• ENSP00000371308
• ENSG00000151849
• ENST00000616936
• ENSP00000477511

Symbol

• CPAP
• LAP
• LIP1
• LAP
• CPAP
• LIP1
• BM032
• MCPH6
• SASS4
• SCKL4
• Sas-4
• CENP-J

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
cellular component	0.7
interacting protein	0.63
transcription factor perturbation	0.61
transcription factor binding site profile	0.6

Protein Classes

PANTHER Classes

Protein / Transferase / Centromere Protein J

Protein / Receptor / Centromere Protein J

DTO Classes

Protein / Enzyme / Transferase / Centromere Protein J

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.53   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.53   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0