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Tbio
CENPJ
Centromere protein J

Protein Classes
Protein Summary
Description
Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). This gene encodes a protein that belongs to the centromere protein family. During cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381884
  • ENSP00000371308
  • ENSG00000151849
  • ENST00000616936
  • ENSP00000477511

Symbol
  • CPAP
  • LAP
  • LIP1
  • LAP
  • CPAP
  • LIP1
  • BM032
  • MCPH6
  • SASS4
  • SCKL4
  • Sas-4
  • CENP-J
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
cellular component
0.7
interacting protein
0.63
transcription factor perturbation
0.61
transcription factor binding site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.65   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.65   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Protein-Protein Interactions (214)
1 – 10 of 214
DPPA3
Tbio
Novelty: 0.03361743
p_int: 0.999998686
p_ni: 0.000001313
p_wrong: 1e-9
Data Source: BioPlex
PLEKHO2
Tdark
Novelty: 0.48296621
p_int: 0.999998013
p_ni: 0.000001986
p_wrong: 1e-9
Score: 0.28
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.999996785
p_ni: 0.000003202
p_wrong: 1.3e-8
Data Source: BioPlex
SH3RF2
Tbio
Family: Enzyme
Novelty: 0.14257663
p_int: 0.960423278
p_ni: 0.000049683
p_wrong: 0.039527039
Score: 0.689
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.894792341
p_ni: 0.000070125
p_wrong: 0.105137534
Score: 0.509
Data Source: BioPlex,STRINGDB
CEP152
Tbio
Novelty: 0.02129779
Score: 0.997
Data Source: STRINGDB
CEP135
Tbio
Novelty: 0.03507768
Score: 0.996
Data Source: STRINGDB
CDK5RAP2
Tbio
Novelty: 0.00956263
Score: 0.995
Data Source: STRINGDB
PLK4
Tchem
Family: Kinase
Novelty: 0.00265851
Score: 0.995
Data Source: STRINGDB
CCP110
Tbio
Novelty: 0.02399511
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  72.65

PubMed score by year
PubTator Score  1667.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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