Tbio CRLF2 Cytokine receptor-like factor 2

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Cytokine Receptor-like Factor 2

Protein / Defense/immunity Protein / Cytokine Receptor-like Factor 2

DTO Classes

Protein / Signaling / Cytokine / Cytokine Receptor-like Factor 2

Protein Summary

Description

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q9HC73
• J3QKD1
• Q5G7M1
• Q9H5R3

Gene Name

• CRLF2

Ensembl ID

• ENST00000381566
• ENSP00000370978
• ENSG00000205755
• ENST00000381567
• ENSP00000370979
• ENST00000400841
• ENSP00000383641

Symbol

• CRL2
• ILXR
• TSLPR
• CRL2
• TSLPR
• CRLF2Y

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
gene perturbation	0.74
cell line	0.6
biological term	0.58
cell type or tissue	0.58

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.56   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 485   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.56   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	1	3	3		68.3
eosinophil percentage of leukocytes	EFO_0007991	1	3	3		68.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3		68.3
eosinophil percentage of leukocytes	EFO_0007991	3		68.3

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Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (8)

Reactome (4)

KEGG (2)

PathwayCommons (1)

WikiPathways (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-7 signaling	25 targets	R-HSA-1266695
Reactome	Signaling by Interleukins	619 targets	R-HSA-449147

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-7 signaling	25 targets	R-HSA-1266695
Signaling by Interleukins	619 targets	R-HSA-449147

Gene Ontology Terms (13)

Functions (2)

Components (5)

Processes (6)

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GO Term	Evidence	Assigned by
cytokine receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
cytokine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (103)

Explore Interacting Targets

1 – 10 of 103

• See Interactions on String-DB

TSLP

Tbio

Novelty: 0.00140333

Score: 0.999

Data Source: Reactome,STRINGDB

IL7R

Tbio

Novelty: 0.00107223

Score: 0.995

Data Source: Reactome,STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00011808

Score: 0.928

Data Source: Reactome,STRINGDB

JAK2

Tclin

Family: Kinase

Novelty: 0.00022894

Score: 0.921

Data Source: STRINGDB

IL7

Tbio

Novelty: 0.00054101

Score: 0.916

Data Source: STRINGDB

IL4

Tbio

Novelty: 0.00005852

Score: 0.879

Data Source: STRINGDB

JAK1

Tclin

Family: Kinase

Novelty: 0.00093625

Score: 0.844

Data Source: STRINGDB

IKZF1

Tbio

Family: TF

Novelty: 0.0016117

Score: 0.838

Data Source: STRINGDB

IL13

Tbio

Novelty: 0.00021435

Score: 0.828

Data Source: STRINGDB

JAK3

Tclin

Family: Kinase

Novelty: 0.00164278

Score: 0.825

Data Source: STRINGDB

Publication Statistics

PubMed Score  131.56

PubMed score by year

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PubTator Score  114.18

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Receptor
Reference proteome
Secreted

GWAS Trait Find Similar Targets

eosinophil count
eosinophil percentage of leukocytes

MGI Phenotype Find Similar Targets

cellular phenotype
digestive/alimentary phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
respiratory system phenotype