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Tbio
CRLF2
Cytokine receptor-like factor 2

Protein Summary
Description
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381566
  • ENSP00000370978
  • ENSG00000205755
  • ENST00000381567
  • ENSP00000370979
  • ENST00000400841
  • ENSP00000383641

Symbol
  • CRL2
  • ILXR
  • TSLPR
  • CRL2
  • TSLPR
  • CRLF2Y
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
gene perturbation
0.74
cell line
0.6
biological term
0.58
cell type or tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.06   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.06   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
TSLP
Tbio
Novelty:  0.00140333
Score:  0.999
Data Source:  Reactome,STRINGDB
IL7R
Tbio
Novelty:  0.00107223
Score:  0.995
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.928
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.921
Data Source:  STRINGDB
IL7
Tbio
Novelty:  0.00054101
Score:  0.916
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.879
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.844
Data Source:  STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
Score:  0.838
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.828
Data Source:  STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.825
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 5
IL5
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL23A
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL12B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL6
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL12A
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-7 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-7 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
3
3
94.7
eosinophil percentage of leukocytes
1
3
3
94.7
mitochondrial heteroplasmy measurement
1
1
1
65.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94.7
eosinophil percentage of leukocytes
3
94.7
mitochondrial heteroplasmy measurement
1
65.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1889506
57914
Rat
RGD:621078
171499
Dog
cytokine receptor like factor 2
VGNC:39621
491709
Cow
cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cytokine receptor like factor 2
Cow
cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281]
Publication Statistics
PubMed Score 141.06
PubMed score by year
PubTator Score 114.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title