Tbio CRLF2 Cytokine receptor-like factor 2

Protein Summary

Description

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q9HC73
• J3QKD1
• Q5G7M1
• Q9H5R3

Gene Name

• CRLF2

Ensembl ID

• ENST00000381566
• ENSP00000370978
• ENSG00000205755
• ENST00000381567
• ENSP00000370979
• ENST00000400841
• ENSP00000383641

Symbol

• CRL2
• ILXR
• TSLPR
• CRL2
• TSLPR
• CRLF2Y

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
gene perturbation	0.74
cell line	0.6
biological term	0.58
cell type or tissue	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Cytokine Receptor-like Factor 2

Protein / Defense/immunity Protein / Cytokine Receptor-like Factor 2

DTO Classes

Protein / Signaling / Cytokine / Cytokine Receptor-like Factor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.79   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 485   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.79   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0