CRLF2
Cytokine receptor-like factor 2
Protein Summary
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
- ENST00000381566
- ENSP00000370978
- ENSG00000205755
- ENST00000381567
- ENSP00000370979
- ENST00000400841
- ENSP00000383641
- CRL2
- ILXR
- TSLPR
- CRL2
- TSLPR
- CRLF2Y
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.76 | ||
gene perturbation | 0.74 | ||
cell line | 0.6 | ||
biological term | 0.58 | ||
cell type or tissue | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.06 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 485 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.06 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 485 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (103)
Nearest Tclin Targets (9)
Upstream (5)
Downstream (4)
1 – 5 of 5
Pathways (8)
Reactome (4)
KEGG (2)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-7 signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-7 signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 1 | 3 | 3 | 94.7 | |||||
eosinophil percentage of leukocytes | 1 | 3 | 3 | 94.7 | |||||
mitochondrial heteroplasmy measurement | 1 | 1 | 1 | 65.4 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 94.7 | |||||
eosinophil percentage of leukocytes | 3 | 94.7 | |||||
mitochondrial heteroplasmy measurement | 1 | 65.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1889506 | 57914 | ||||||
Rat | RGD:621078 | 171499 | ||||||
Dog | cytokine receptor like factor 2 | VGNC:39621 | 491709 | |||||
Cow | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | cytokine receptor like factor 2 | |||||
Cow | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | |||||
Publication Statistics
PubMed Score 141.06
PubMed score by year
PubTator Score 114.18
PubTator score by year
Related Publications
Text Mined References (62)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
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