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Tbio
CRLF2
Cytokine receptor-like factor 2

Protein Summary
Description
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381566
  • ENSP00000370978
  • ENSG00000205755
  • ENST00000381567
  • ENSP00000370979
  • ENST00000400841
  • ENSP00000383641

Symbol
  • CRL2
  • ILXR
  • TSLPR
  • CRL2
  • TSLPR
  • CRLF2Y
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
gene perturbation
0.74
cell line
0.6
biological term
0.58
cell type or tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.48   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.48   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-7 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-7 signaling
Signaling by Interleukins
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (103)
1 – 10 of 103
TSLP
Tbio
Novelty: 0.0015318
Score: 0.999
Data Source: Reactome,STRINGDB
IL7R
Tbio
Novelty: 0.00182378
Score: 0.995
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00013496
Score: 0.928
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00028252
Score: 0.921
Data Source: STRINGDB
IL7
Tbio
Novelty: 0.00089292
Score: 0.916
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00010156
Score: 0.879
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00136831
Score: 0.844
Data Source: STRINGDB
IKZF1
Tbio
Family: TF
Novelty: 0.00201134
Score: 0.838
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00043714
Score: 0.828
Data Source: STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00219647
Score: 0.825
Data Source: STRINGDB
Publication Statistics
PubMed Score  89.48

PubMed score by year
PubTator Score  114.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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