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Tbio
SENP2
Sentrin-specific protease 2

Protein Classes
Protein Summary
Description
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplie ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296257
  • ENSP00000296257
  • ENSG00000163904

Symbol
  • KIAA1331
  • AXAM2
  • SMT3IP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor perturbation
0.96
biological process
0.95
histone modification site profile
0.87
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.62   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 646   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.62   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 646   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
1
7.1
58.6
1
1
0
1
25.2
diastolic blood pressure
1
1
1
22.9
electrocardiography
1
1
4
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
7.1
58.6
0
1
25.2
diastolic blood pressure
1
22.9
electrocardiography
4
15.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 2
VGNC:8851
460902
Macaque
SUMO1/sentrin/SMT3 specific peptidase 2
700717
Mouse
MGI:1923076
75826
Rat
RGD:708378
78973
Dog
SUMO specific peptidase 2
VGNC:46006
478661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 2
Macaque
SUMO1/sentrin/SMT3 specific peptidase 2
Mouse
Rat
Dog
SUMO specific peptidase 2
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HC62-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing and activation of SUMO
Reactome
SUMO is proteolytically processed
Reactome
SUMOylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Processing and activation of SUMO
SUMO is proteolytically processed
SUMOylation
Protein-Protein Interactions (43)
1 – 10 of 43
SUMO3
Tbio
Novelty: 0.03096465
p_int: 0.999999893
p_ni: 1.06e-7
p_wrong: 1e-9
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
USP28
Tbio
Family: Enzyme
Novelty: 0.02432294
p_int: 0.994741058
p_ni: 0.005258942
Score: 0.416
Data Source: BioPlex,STRINGDB
PGK2
Tbio
Family: Kinase
Novelty: 0.00832045
p_int: 0.888310129
p_ni: 0.111688748
p_wrong: 0.000001123
Score: 0.232
Data Source: BioPlex,STRINGDB
SUMO2
Tbio
Novelty: 0.00366833
Score: 0.995
Data Source: Reactome,STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.995
Data Source: Reactome,STRINGDB
RANGAP1
Tbio
Family: Enzyme
Novelty: 0.00917672
Score: 0.95
Data Source: STRINGDB
NUP153
Tbio
Novelty: 0.00696568
Score: 0.926
Data Source: STRINGDB
DVL3
Tbio
Novelty: 0.01606014
Score: 0.825
Data Source: STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.821
Data Source: STRINGDB
DVL2
Tbio
Novelty: 0.00833084
Score: 0.802
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.62

PubMed score by year
PubTator Score  41.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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