Tbio SENP2 Sentrin-specific protease 2

Protein Summary

Description

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9HC62
• B4DQ42
• Q8IW97
• Q96SR2
• Q9P2L5

Gene Name

• SENP2

Ensembl ID

• ENST00000296257
• ENSP00000296257
• ENSG00000163904

Symbol

• KIAA1331
• AXAM2
• SMT3IP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor perturbation	0.96
biological process	0.95
histone modification site profile	0.87
transcription factor binding site profile	0.76

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Sentrin-specific Protease 2

DTO Classes

Protein / Enzyme / Protease / Sentrin-specific Protease 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.77   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 646   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.77   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 646   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

SUMO3

Tbio

Novelty:  0.03096465

p_int:  0.999999893

p_ni:  1.06e-7

p_wrong:  1e-9

Score:  0.98

Data Source:  BioPlex,Reactome,STRINGDB

USP28

Tchem

Family:  Enzyme

Novelty:  0.02432294

p_int:  0.994741058

p_ni:  0.005258942

Score:  0.416

Data Source:  BioPlex,STRINGDB

PGK2

Tbio

Family:  Kinase

Novelty:  0.00832045

p_int:  0.888310129

p_ni:  0.111688748

p_wrong:  0.000001123

Score:  0.232

Data Source:  BioPlex,STRINGDB

SUMO2

Tbio

Novelty:  0.00366833

Score:  0.995

Data Source:  Reactome,STRINGDB

SUMO1

Tbio

Novelty:  0.00137629

Score:  0.995

Data Source:  Reactome,STRINGDB

RANGAP1

Tbio

Family:  Enzyme

Novelty:  0.00917672

Score:  0.95

Data Source:  STRINGDB

NUP153

Tbio

Novelty:  0.00696568

Score:  0.926

Data Source:  STRINGDB

DVL3

Tbio

Novelty:  0.01606014

Score:  0.825

Data Source:  STRINGDB

DVL1

Tchem

Novelty:  0.00356876

Score:  0.821

Data Source:  STRINGDB

DVL2

Tbio

Novelty:  0.00833084

Score:  0.802

Data Source:  STRINGDB

Nearest Tclin Targets (1)

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Downstream (1)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Wnt signaling pathway

Pathways (25)

Reactome (5)

KEGG (2)

WikiPathways (18)

Metabolism of proteins (R-HSA-392499)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Processing and activation of SUMO	10 targets	R-HSA-3215018
Reactome	SUMO is proteolytically processed	6 targets	R-HSA-3065679
Reactome	SUMOylation	176 targets	R-HSA-2990846

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Processing and activation of SUMO	10 targets	R-HSA-3215018
SUMO is proteolytically processed	6 targets	R-HSA-3065679
SUMOylation	176 targets	R-HSA-2990846

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (30)

Functions (3)

Components (6)

Processes (21)

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1 – 3 of 3

GO Term	Evidence	Assigned by
SUMO-specific endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl
SUMO-specific isopeptidase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (7)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	3	3	2	7.1	88.6
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		81.7
BMI-adjusted hip circumference	EFO_0008039	2	3	4		77.8
urate measurement	EFO_0004531	2	2	2		40.6
electrocardiography	EFO_0004327	1	1	4		26.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	2	7.1	88.6
sex hormone-binding globulin measurement	EFO_0004696	6		81.7
BMI-adjusted hip circumference	EFO_0008039	4		77.8
urate measurement	EFO_0004531	2		40.6
electrocardiography	EFO_0004327	4		26.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Membrane
mRNA transport
Nuclear pore complex
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
diastolic blood pressure
electrocardiography
glomerular filtration rate
sex hormone-binding globulin measurement
type II diabetes mellitus
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
embryo phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SUMO specific peptidase 2	VGNC:8851	460902
Macaque	SUMO1/sentrin/SMT3 specific peptidase 2		700717
Mouse	SUMO/sentrin specific peptidase 2	MGI:1923076	75826
Rat	SUMO specific peptidase 2	RGD:708378	78973
Dog	SUMO specific peptidase 2	VGNC:46006	478661

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SUMO specific peptidase 2
Macaque	SUMO1/sentrin/SMT3 specific peptidase 2
Mouse	SUMO/sentrin specific peptidase 2
Rat	SUMO specific peptidase 2
Dog	SUMO specific peptidase 2

Publication Statistics

PubMed Score 4.77

PubMed score by year

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PubTator Score 41.87

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Related Publications

Text Mined References (48)

GeneRif Annotations (30)

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PMID	Year	Title