Tchem SENP2 Sentrin-specific protease 2

Protein Summary

Description

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9HC62
• B4DQ42
• Q8IW97
• Q96SR2
• Q9P2L5

Gene Name

• SENP2

Ensembl ID

• ENST00000296257
• ENSP00000296257
• ENSG00000163904

Symbol

• KIAA1331
• AXAM2
• SMT3IP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor perturbation	0.96
biological process	0.95
histone modification site profile	0.87
transcription factor binding site profile	0.76

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Sentrin-specific Protease 2

DTO Classes

Protein / Enzyme / Protease / Sentrin-specific Protease 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 646   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 646   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0