SENP2
Sentrin-specific protease 2
Protein Classes
Protein Summary
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplie ...more
- ENST00000296257
- ENSP00000296257
- ENSG00000163904
- KIAA1331
- AXAM2
- SMT3IP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.96 | ||
transcription factor perturbation | 0.96 | ||
biological process | 0.95 | ||
histone modification site profile | 0.87 | ||
transcription factor binding site profile | 0.76 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.62 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 646 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.62 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 646 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 2 | 1 | 7.1 | 58.6 | ||||
1 | 1 | 0 | 1 | 25.2 | |||||
diastolic blood pressure | 1 | 1 | 1 | 22.9 | |||||
electrocardiography | 1 | 1 | 4 | 15.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 1 | 7.1 | 58.6 | ||||
0 | 1 | 25.2 | |||||
diastolic blood pressure | 1 | 22.9 | |||||
electrocardiography | 4 | 15.5 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SUMO specific peptidase 2 | VGNC:8851 | 460902 | |||||
Macaque | SUMO1/sentrin/SMT3 specific peptidase 2 | 700717 | ||||||
Mouse | MGI:1923076 | 75826 | ||||||
Rat | RGD:708378 | 78973 | ||||||
Dog | SUMO specific peptidase 2 | VGNC:46006 | 478661 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SUMO specific peptidase 2 | |||||
Macaque | SUMO1/sentrin/SMT3 specific peptidase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SUMO specific peptidase 2 | |||||
Protein Structure (8 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 8
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (25)
Reactome (5)
KEGG (2)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Processing and activation of SUMO | ||||
Reactome | SUMO is proteolytically processed | ||||
Reactome | SUMOylation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Processing and activation of SUMO | ||||
SUMO is proteolytically processed | ||||
SUMOylation | ||||
Gene Ontology Terms (30)
Functions (3)
Components (6)
Processes (21)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (43)
1 – 10 of 43
SUMO3
Novelty: 0.03096465
p_int: 0.999999893
p_ni: 1.06e-7
p_wrong: 1e-9
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
USP28
Family: Enzyme
Novelty: 0.02432294
p_int: 0.994741058
p_ni: 0.005258942
Score: 0.416
Data Source: BioPlex,STRINGDB
PGK2
Family: Kinase
Novelty: 0.00832045
p_int: 0.888310129
p_ni: 0.111688748
p_wrong: 0.000001123
Score: 0.232
Data Source: BioPlex,STRINGDB
SUMO2
Novelty: 0.00366833
Score: 0.995
Data Source: Reactome,STRINGDB
SUMO1
Novelty: 0.00137629
Score: 0.995
Data Source: Reactome,STRINGDB
RANGAP1
Family: Enzyme
Novelty: 0.00917672
Score: 0.95
Data Source: STRINGDB
NUP153
Novelty: 0.00696568
Score: 0.926
Data Source: STRINGDB
DVL3
Novelty: 0.01606014
Score: 0.825
Data Source: STRINGDB
DVL1
Novelty: 0.00356876
Score: 0.821
Data Source: STRINGDB
DVL2
Novelty: 0.00833084
Score: 0.802
Data Source: STRINGDB
Publication Statistics
PubMed Score 4.62
PubMed score by year
PubTator Score 41.87
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait