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Tbio
SLC24A3
Sodium/potassium/calcium exchanger 3

Protein Summary
Description
Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328041
  • ENSP00000333519
  • ENSG00000185052
  • ENST00000613834
  • ENSP00000482967

Symbol
  • NCKX3
  • NCKX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.79
disease perturbation
0.74
gene perturbation
0.74
disease
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (42)
1 – 10 of 42
RIN2
Tbio
Novelty:  0.0527887
Score:  0.755
Data Source:  STRINGDB
TMEM212
Tdark
Novelty:  0.94290731
Score:  0.742
Data Source:  STRINGDB
CFAP61
Tdark
Novelty:  0.58493403
Score:  0.73
Data Source:  STRINGDB
KCNH6
Tclin
Family:  IC
Novelty:  0.01126636
Score:  0.674
Data Source:  STRINGDB
SPATC1
Tdark
Novelty:  0.26477487
Score:  0.671
Data Source:  STRINGDB
KCNK10
Tclin
Family:  IC
Novelty:  0.01313558
Score:  0.647
Data Source:  STRINGDB
OAZ1
Tbio
Family:  Enzyme
Novelty:  0.0224953
Score:  0.634
Data Source:  STRINGDB
CCDC15
Tdark
Novelty:  1.32419957
Score:  0.624
Data Source:  STRINGDB
SLC12A4
Tbio
Family:  Transporter
Novelty:  0.01077688
Score:  0.612
Data Source:  STRINGDB
KCNK16
Tbio
Family:  IC
Novelty:  0.09168043
Score:  0.589
Data Source:  STRINGDB
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Calcium exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium/Calcium exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
10
10
92.9
hip circumference
1
11
11
92.8
mean platelet volume
3
2
3
91.5
2
2
0
1.1
83.4
1
1
0
1.2
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
92.9
hip circumference
11
92.8
mean platelet volume
3
91.5
0
1.1
83.4
0
1.2
82.5
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 3
VGNC:14297
458121
Macaque
solute carrier family 24 member 3
702212
Mouse
MGI:2137513
94249
Rat
RGD:69256
85267
Dog
solute carrier family 24 member 3
VGNC:46287
607712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 3
Macaque
solute carrier family 24 member 3
Mouse
Rat
Dog
solute carrier family 24 member 3
Publication Statistics
PubMed Score 17.03
PubMed score by year
PubTator Score 20.82
PubTator score by year