Tbio PCDH9 Protocadherin-9

Protein Summary

Description

Potential calcium-dependent cell-adhesion protein. This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q9HC56
• A2A6U1
• Q5VT83
• Q7Z3U0
• Q8N3K7

Gene Name

• PCDH9

Ensembl ID

• ENST00000377865
• ENSP00000367096
• ENSG00000184226
• ENST00000544246
• ENSP00000442186

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
small molecule perturbation	0.77
gene perturbation	0.74
protein domain	0.73
histone modification site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.24   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.24   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0