Tchem CBX8 Chromobox protein homolog 8

Protein Summary

Description

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Uniprot Accession IDs

• Q9HC52
• Q96H39
• Q9NR07

Gene Name

• CBX8

Ensembl ID

• ENST00000269385
• ENSP00000269385
• ENSG00000141570

Symbol

• PC3
• RC1
• PC3
• RC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
transcription factor	0.8
histone modification site profile	0.71
biological process	0.64
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 768.26   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 612   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 768.26   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 612   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0