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Tchem
CBX8
Chromobox protein homolog 8

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269385
  • ENSP00000269385
  • ENSG00000141570

Symbol
  • PC3
  • RC1
  • PC3
  • RC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
transcription factor
0.8
histone modification site profile
0.71
biological process
0.64
small molecule perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 498.56   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 612   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 498.56   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 612   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
17.2
platelet crit
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
17.2
platelet crit
1
8.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromobox 8
VGNC:12039
468347
Mouse
MGI:1353589
30951
Rat
RGD:1565375
303731
Dog
chromobox 8
VGNC:38769
608591
Horse
chromobox 8
VGNC:16100
100050416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromobox 8
Mouse
Rat
Dog
chromobox 8
Horse
chromobox 8
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HC52-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (174)
1 – 10 of 174
PCGF2
Tbio
Novelty: 0.02148755
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
PHC1
Tbio
Novelty: 0.01530622
p_int: 0.999999997
p_ni: 3e-9
Score: 0.99
Data Source: BioPlex,STRINGDB
SFTPC
Tbio
Novelty: 0.00154396
p_int: 0.999977858
p_ni: 0.000022142
Score: 0.219
Data Source: BioPlex,STRINGDB
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.998641548
p_ni: 0.001325491
p_wrong: 0.000032961
Score: 0.966
Data Source: BioPlex,STRINGDB
RING1
Tbio
Family: Enzyme
Novelty: 0.00729948
Score: 0.992
Data Source: STRINGDB
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
Score: 0.991
Data Source: STRINGDB
PHC2
Tbio
Novelty: 0.01943349
Score: 0.984
Data Source: STRINGDB
BMI1
Tbio
Novelty: 0.00158043
Score: 0.983
Data Source: STRINGDB
PHC3
Tbio
Novelty: 0.00091911
Score: 0.982
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  498.56

PubMed score by year
PubTator Score  1572.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer