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Tbio
EML4
Echinoderm microtubule-associated protein-like 4

Protein Summary
Description
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318522
  • ENSP00000320663
  • ENSG00000143924
  • ENST00000402711
  • ENSP00000385059

Symbol
  • C2orf2
  • EMAPL4
  • C2orf2
  • ELP120
  • EMAP-4
  • EMAPL4
  • ROPP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
microRNA
0.81
transcription factor perturbation
0.8
transcription factor
0.79
cell type or tissue
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.62   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.62   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
EML1
Tbio
Novelty:  0.02262549
p_int:  0.999993669
p_ni:  0.000006331
Score:  0.935
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999936798
p_ni:  0.000063202
Data Source:  BioPlex
TUBB2A
Tclin
Novelty:  0.00902924
p_int:  0.997125554
p_ni:  0.002874446
Score:  0.69
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.99138697
p_ni:  0.00861303
Score:  0.155
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.96601376
p_ni:  0.03398624
Score:  0.264
Data Source:  BioPlex,STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
p_int:  0.933092514
p_ni:  0.066907486
Score:  0.566
Data Source:  BioPlex,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.883167901
p_ni:  0.116832099
Data Source:  BioPlex
TUBB
Tclin
Novelty:  0.0038007
p_int:  0.784995523
p_ni:  0.215004477
Score:  0.755
Data Source:  BioPlex,STRINGDB
PRPS1
Tbio
Family:  Kinase
Novelty:  0.01139656
p_int:  0.781126394
p_ni:  0.218873579
p_wrong:  2.6e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.77950287
p_ni:  0.22049713
Data Source:  BioPlex
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (168)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
PD-L1 expression and PD-1 checkpoint pathway in cancer
KEGG
Pathways in cancer
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Pathways in cancer
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
80.5
1
1
0
2.3
64
BMI-adjusted hip circumference
1
3
3
54.2
IGF-1 measurement
1
1
1
44.2
high density lipoprotein cholesterol measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
80.5
0
2.3
64
BMI-adjusted hip circumference
3
54.2
IGF-1 measurement
1
44.2
high density lipoprotein cholesterol measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
echinoderm microtubule associated protein like 4
VGNC:241
459180
Mouse
MGI:1926048
78798
Rat
RGD:1304690
313861
Dog
echinoderm microtubule associated protein like 4
VGNC:40349
483048
Horse
echinoderm microtubule associated protein like 4
VGNC:17567
100053784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
echinoderm microtubule associated protein like 4
Mouse
Rat
Dog
echinoderm microtubule associated protein like 4
Horse
echinoderm microtubule associated protein like 4
Publication Statistics
PubMed Score 342.62
PubMed score by year
PubTator Score 289.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title