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Tclin
NOD2
Nucleotide-binding oligomerization domain-containing protein 2

Protein Summary
Description
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189). This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300589
  • ENSP00000300589
  • ENSG00000167207
  • ENST00000647318
  • ENSP00000495993

Symbol
  • CARD15
  • IBD1
  • CD
  • ACUG
  • BLAU
  • IBD1
  • YAOS
  • BLAUS
  • NLRC2
  • NOD2B
  • CARD15
  • CLR16.3
  • PSORAS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
molecular function
0.95
virus perturbation
0.83
phenotype
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2062.86   (req: < 5)
Gene RIFs: 599   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2062.86   (req: >= 5)
Gene RIFs: 599   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 63
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 91
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1