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Tclin
NOD2
Nucleotide-binding oligomerization domain-containing protein 2

Protein Summary
Description
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189). This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300589
  • ENSP00000300589
  • ENSG00000167207
  • ENST00000647318
  • ENSP00000495993

Symbol
  • CARD15
  • IBD1
  • CD
  • ACUG
  • BLAU
  • IBD1
  • YAOS
  • BLAUS
  • NLRC2
  • NOD2B
  • CARD15
  • CLR16.3
  • PSORAS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
molecular function
0.95
virus perturbation
0.83
phenotype
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1871.6   (req: < 5)
Gene RIFs: 599   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1871.6   (req: >= 5)
Gene RIFs: 599   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 63
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
mifamurtide
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
3
0
1.6
99.6
Oral ulcer
1
1
0
1.1
96.9
1
1
0
1.5
62.9
childhood onset asthma
2
1
0
1.2
35.6
2
1
0
1.1
24.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
99.6
Oral ulcer
0
1.1
96.9
0
1.5
62.9
childhood onset asthma
0
1.2
35.6
0
1.1
24.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding oligomerization domain containing 2
VGNC:13750
454083
Macaque
nucleotide binding oligomerization domain containing 2
695542
Mouse
MGI:2429397
257632
Rat
RGD:1306368
291912
Dog
nucleotide binding oligomerization domain containing 2
VGNC:43878
487286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding oligomerization domain containing 2
Macaque
nucleotide binding oligomerization domain containing 2
Mouse
Rat
Dog
nucleotide binding oligomerization domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HC29-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (82)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-1 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deubiquitination
Immune System
Innate Immune System
Interleukin-1 family signaling
Gene Ontology Terms (73)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (265)
1 – 10 of 265
RIPK2
Tchem
Family: Kinase
Novelty: 0.00574043
Score: 0.992
Data Source: Reactome,STRINGDB
ATG16L1
Tbio
Novelty: 0.0031765
Score: 0.991
Data Source: STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.97
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.969
Data Source: STRINGDB
CARD9
Tbio
Family: Enzyme
Novelty: 0.00547101
Score: 0.969
Data Source: Reactome,STRINGDB
BIRC3
Tchem
Novelty: 0.00189613
Score: 0.961
Data Source: STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
Score: 0.96
Data Source: STRINGDB
TNFAIP3
Tbio
Novelty: 0.00257088
Score: 0.957
Data Source: Reactome,STRINGDB
MAVS
Tbio
Novelty: 0.00241215
Score: 0.956
Data Source: STRINGDB
CYLD
Tbio
Family: Enzyme
Novelty: 0.00215465
Score: 0.955
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1871.60

PubMed score by year
PubTator Score  1407.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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